PCORnet® Studies
Designating your project as a PCORnet® Study opens the door to enhanced visibility, expert support, validated tools, and integrated patient partnership. It’s a strategic path to maximizing impact and accelerating the translation of your research into real-world benefits.
PCORnet® Studies are national in scope,
- include patient engagement throughout the project lifecycle,
- are committed to broad dissemination of findings,
- leverage PCORnet resources to improve the efficiency of patient-centered research (e.g., the PCORnet® Common Data Model (CDM), single IRB, engagement resources, data sharing agreements, etc.), and
- help build learning systems by sharing progress and lessons learned.
Research Made Easier
Learn about resources offered to researchers interested in using the PCORnet infrastructure.
PCORnet® Studies with primary results publications.
Study Data Current as of April 14, 2026.
Search all PCORnet® Studies below, filtering by Status, Funder or Therapeutic Area, or search by keyword.
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Research Question(s): Are non-stimulants equally appropriate first line medications as stimulants for treating ADHD in school age youth, and which youth are most likely to benefit from which approa...
Research Question(s): Which children benefit from which treatment for sinus and ear infections?
Research Question(s): Do individuals' beliefs about the trustworthiness of a university and other research organizations (e.g., academic medical centers) correlate to how much they trust researcher...
Research Question(s): Oregon implemented new Medicaid policies intended to increase referrals to connect patients endorsing specific social risks with local non-medical services. How do Ore...
Research Question(s): The study focuses on making autism research more reliable and widely applicable. We are creating the Autism Replication, Validation, and Reproducibility (AR²) Center to en...
Research Question(s): For children hospitalized with pneumonia, skin infections, or urinary infections, do they recover better and have fewer side effects with a 5-day course of antibiotics, or a 1...
Research Question(s): 1) In hospitalized patients with severe infections, does the antibiotic combination workhorse, vancomycin and piperacillin/tazobactam (VPT), cause more kidney injury than anot...
Research Question(s): Can children with obesity achieve meaningful improvements in their health with fewer hours of treatment than currently recommended?
Research Question(s): Can we determine which medicine is the safest and most effective at treating kids with Crohn's disease or ulcerative colitis when the first medicine they take does not work fo...
Research Question(s): How can we use nationally distributed healthcare data infrastructure to (1) improve the capacity of data and information systems to conduct monitoring and surveillance and (...
Research Question(s): Does access to new, text messaging-based communications tools help teenagers and adults with IBD (Crohn's Disease and Ulcerative Colitis) feel better able to manage their cond...
Research Question(s): Is a newer oral migraine preventive medication (atogepant) more effective for treating migraines than two older medications (propranolol, topiramate), each of which is commonl...
Research Question(s): How does the quality of asthma care - including timely diagnosis, assessment, immunization, medication prescription, and access to testing - vary when comparing Latino adults ...
Research Question(s): Do smaller breathing tubes prevent long-term problems with breathing, speaking and swallowing? Are smaller breathing tubes as good as larger breathing tubes for getting pati...
Research Question(s): In this study, we are comparing two commonly used beta-blockers-carvedilol and metoprolol succinate-in people who have heart failure and an implanted defibrillator. We want to...
Research Question(s): Is implantable cardioverter-defibrillator beneficial in eligible heart failure patients with low arrhythmia risk?
Research Question(s): IRIS-CKD is a project focused on improving how doctors check for and treat chronic kidney disease (CKD) in people with type 2 diabetes (T2D). The main goals of the project are...
Research Question(s):
1) What are the engagement strategies needed for individuals living with NDD and CHD?
2) What metrics (such as surveys, focus groups, etc.) can be employed to measure engageme...
Research Question(s): Can a data resource be created to strengthen urinary stone disease research that will generate new knowledge that improves the health of all individuals with urinary stone dis...
Research Question(s): Can we develop a consensus-based strategy that comprehensively measures TTP-associated cognitive function impacts from the patient perspective?
Research Question(s): Can large language models - an advanced form of artificial intelligence (AI) - improve the generalizability of patient information extraction and clinical phenotyping across d...
Research Question(s): What is the best way to encourage ICU clinicians to consistently and completely implement the ABCDEF Bundle in their care of mechanically ventilated patients?
Research Question(s): For adults 50 and older who have had a recent fracture, can a Fracture Liaison Service that includes a patient navigator, access to a bone health provider, and increased use o...
Research Question(s): Can we identify optimal immunosuppression management strategies for kidney transplant patients leveraging real world data?
Research Question(s): Can we improve the testing and treatment of high cholesterol in patients who have been hospitalized for a cardiac event by providing education to doctors and patients?
Research Question(s): How can we measure the process of co-creation in a way that is pragmatic, valid, reliable, and associated with meaningful engagement outcomes?
Research Question(s): In this study, the research team wanted to learn if taking HCQ was safe and prevented COVID-19 in healthcare workers.
Research Question(s): The study will answer important questions patients are asking about the link between diabetes and COVID-19. To what extent does COVID-19 cause worse glycemic control, vas...
Research Question(s): Did a community rise in COVID-19 hospitalizations and deaths contribute to an increase in the risk of overdose among PCORnet patients? What role did public health and ...
Research Question(s): Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease, affecting over 3 million individuals worldwide and causing progressive lung function deteriorati...
VictORION-INCLUSION: Evaluating Inclisiran for Cholesterol Management in Heart Disease (V-INCLUSION)
Research Question(s): Can inclisiran be an effective solution to improve low-density lipoprotein-cholesterol management and close care gaps in an inclusive Atherosclerotic Cardiovascular Disease (...
Measurement Matters: Refining and Validating a Patient-Centered Outcomes Research Engagement Measure
Research Question(s): Can we develop a concise way to measure the extent to which researchers engaging older adults in research projects are doing so effectively and can we assign a score that...
Research Question(s): The research team is recruiting 900 English- and Spanish-speaking parent-infant pairs from six primary care clinics. The team is assigning the pairs by chance to receive eith...
Research Question(s): How are patients' cancer screening practices impacted by bariatric surgery for weight loss?
Research Question(s): Can a research registry of people working in healthcare help to answer important questions about the COVID-19 pandemic on medications, vaccines and healthcare worker well-be...
Research Question(s): Can the use of EHR data develop predictive tools to assist healthcare providers in reaching earlier diagnoses and interventions, and improve the diagnostic journey and clini...
Research Question(s): How does antibiotic use before age two affect weight and growth in children?
Research Question(s): We don’t know much about the long-term effectiveness of bariatric interventions. Can we use PCORnet to compare compare weight loss and safety among three popular bariatric ...
Research Question(s): Can remote blood pressure monitoring with cellular devices and tailored lifestyle coaching more effectively help reduce blood pressure and prevent secondary (another) str...
Research Question(s):Can we reduce the number of people who die from atherosclerotic cardiovascular disease (ASCVD) related deaths by using PCSK9 medicines to lower their cholesterol?
Research Question(s): What are the long term health effects of COVID-19 after a person has recovered from infection? How can we better detect, predict, treat these health effects and preven...
Research Question: Which dose of daily aspirin offers the right balance of effectiveness and minimal risk of bleeding? Can PCORnet be used to find the answer using a clinical trial model wherein pa...
Research Question(s): What is the occurrence of vascular, bleeding, or other events in Atrial Fibrillation or Atrial Flutter Patients patients?
Research Question(s): How well are clinics and patients controlling blood pressure, and would new programs or technologies help improve blood pressure control?
Research Question(s): What are the long term health effects of COVID-19 after a person has recovered from infection? How can we better detect, predict, and treat these health effects and pr...
Research Question(s): Which treatment options are most likely to improve important clinical outcomes in my child (or patient) with LGS? My child has hundreds of seizures a week, and multipl...
Research Question(s): Can we better understand why patients with type-2 diabetes may not receive guideline-recommended screening for diabetic kidney disease? Which medications may be most e...
Research Question(s): In patients with type 2 diabetes, are SGLT2 inhibitors or GLP-1 recent agonists better for preventing heart attack, stroke, blood vessel disease, heart failure, kidney di...
Research Question(s): Can we find ways to more accurately describe how suitable data are to answer a specific research question? What are the tools that can be used across studies to consis...
Research Question(s): How does receiving current recommended care affect long-term outcomes and healthcare needs amongst the numerous rare disease subtypes of congenital heart defects? What...
Research Question(s): What is the comparative impact of different shelter-in-place/reopening policies, overall and in vulnerable populations, on patient-reported financial insecurity, mental h...
Research Question(s): Which care options work, for whom, and under which circumstances in order to improve symptom management, treatment outcomes and quality of life among NET patients? Com...
Research Question(s): Can a research registry of patients with metastatic renal cell carcinoma (mRCC) patients help us better understand cancer management and health-related quality of life whil...
Research Question(s): How often is intensive behavioral therapy (IBT) being utilized in primary care and how has it impacted weight and diabetes outcomes for patients with and at-risk of type ...
Research Question(s): Can repurposed medications reduce symptoms of non-hospitalized participants with mild to moderate COVID-19?
Research Question(s): This trial will compare how patients with inactive spondyloarthritis on tumor necrosis factor inhibitor (TNFi) treatment respond to three treatment options that doctors cur...
Research Question(s): What are the differences in stone clearance and the lived experiences of youth, age 8-21 years, following ureteroscopy (URS), shock wave lithotripsy (SWL), and percutaneous n...
Research Question(s): Which blood pressure monitoring strategies, urine protein monitoring strategies, and blood pressure medication strategies are most effective in preserving kidney function i...
Research Question(s): How do patients with non-alcoholic steatohepatitis (NASH) or non-alcoholic fatty liver disease (NAFLD) compare with those who do not have these diagnoses? How is risk ...
Research Question(s): Can PCORnet be leveraged to implement patient-reported outcome measures in routine clinical practice for heart failure patients at three different institutions?
Research Question(s): What are the features of primary care telemedicine programs that have been newly implemented or expanded in response to the COVID-19 pandemic, and how do different population...
Research Question(s): Does mobile phone-delivered computerized cognitive behavioral therapy provide a greater benefit for daily pain and depression in adult patients with sickle cell disease than ...
Research Question(s): How do six classes of commonly prescribed medications influence weight, risk for diabetes, and cholesterol over time?
Research Question(s): Can a statin help prevent dementia and disability in adults aged 75 or older, as well as heart attacks and other cardiovascular-related deaths, while not increasing risks of ...