Page last updated July 09, 2026

Study Design: Intervention Trial
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement, Clinical Research
Collaboration Agreement
Principal Investigator: Michelle Denburg
Institution: The Children’s Hospital of Philadelphia
PCORnet® Network Partner: PEDSnet
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2026
Study Duration: 2026 – 2031
Participating PCORnet® Clinical Research Networks: GPC, INSIGHT, OneFlorida+, PEDSnet, PaTH, REACHnet, STAR
Therapeutic Area: Nephrology, Rare Diseases
Status: Not yet recruiting

Research Question(s):

1) What blood pressure threshold should be targeted for kidney and cardiovascular protection in children with CKD?

2) Should RAASi be first-line anti-hypertensive therapy for all children with CKD?