Recruiting

Comparing Two Ways To Help Older Adults and Their Family Caregivers Transition Home From the Hospital

Posted on by Jodi Snare

Page last updated October 08, 2026

ClinicalTrials.gov#: NCT07661355
Study Design: Intervention Trial
PCORnet Infrastructure: Single IRB, Patient partners or engagement
Principal Investigator: Thomas Houston and Marc Kowalkowski
Institution: Wake Forest University School Health Sciences
PCORnet® Network Partner: STAR
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2026
Study Duration: 2026 – 2032
Participating PCORnet® Clinical Research Networks: GPC, OneFlorida+, PaTH, STAR
Therapeutic Area: Healthcare Delivery, Engagement Methods, Mental and Behavioral Health
Status: Recruiting

Research Question(s):

This study investigates better ways to help people after they leave the hospital and how to involve their families in this process. The main goal is to see if adding family support to a patient-centered hospital-to-home intervention helps patients stay safely at home, spend fewer days back in the emergency room or going back into the hospital.

Observational Approach versus Surgical Intervention for Stones (OASIS)

Posted on by Jodi Snare

Page last updated November 5, 2026

ClinicalTrials.gov#: NCT07718802
Study Website: https://www.oasistrial.org/
Study Design: Intervention Trial
PCORnet Infrastructure: Single IRB, Patient partners or engagement, Clinical Research Collaboration Agreement
Principal Investigator: Gregory Tasian
Institution: The Children's Hospital of Philadelphia
PCORnet® Network Partner: PEDSnet
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2026
Study Duration: 2026 – 2031
Participating PCORnet® Clinical Research Networks: ADVANCE, GPC, INSIGHT, OneFlorida+, PEDSnet, PaTH, REACHnet, STAR
Therapeutic Area: Nephrology
Status: Recruiting

Research Question(s):

Whether observation or upfront surgery results in less life disruption from asymptomatic (showing no symptoms) kidney stones for children and adults.

Comparative Effectiveness of Different Techniques for Repeat Ablation After Failed Initial Ablation for Persistent Atrial Fibrillation

Posted on by Jodi Snare

Page last updated August 06, 2026

ClinicalTrials.gov#: NCT06988202
Study Design: Intervention Trial
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement
Principal Investigator: Jonathan Steinberg
Institution: University of Rochester
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2025
Study Duration: 2025 – 2031
Participating PCORnet® Clinical Research Networks: GPC, PaTH, STAR
Therapeutic Area: Cardiovascular, Engagement Methods, Healthcare Delivery, Health Disparities
Status: Recruiting

Research Question(s):

Many people with persistent atrial fibrillation have symptoms that continue or return after their first ablation procedure. When this happens, patients and doctors often consider a second ablation. However, there is not enough evidence to know which repeat ablation approach gives patients the best chance of feeling better and reducing future AF-related care.

REPEAT-AF asks whether adding left atrial posterior wall isolation to a repeat pulmonary vein isolation procedure improves symptoms, reduces atrial fibrillation recurrence, lowers AF burden, and reduces cardiovascular-related healthcare use compared with repeat pulmonary vein isolation alone. In plain language, the study asks: For adults who still have atrial fibrillation after a first ablation for persistent AF, does a more comprehensive repeat ablation help patients feel better and have fewer AF-related problems than the standard repeat ablation approach?

Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children: Which Children Benefit from Which Treatment? (MEASURE Trial)

Posted on by Jodi Snare

Page last updated November 5, 2026

ClinicalTrials.gov#: NCT07730814
Study Design: Intervention Trial
PCORnet Infrastructure: Single IRB, Patient partners or engagement, Clinical Research Collaboration Agreement
Principal Investigator: Nader Shaikh
Institution: University of Pittsburgh
PCORnet® Network Partner: PaTH
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2025
Study Duration: 2026 - 2032
Participating PCORnet® Clinical Research Networks: PEDSnet, PaTH, STAR
Therapeutic Area: Infectious Disease
Status: Recruiting

Research Question(s): Which children benefit from which treatment for sinus and ear infections?

Teaming Researchers Up with Stakeholders to Test Trustworthy Engagement and Measure: TRUST TEAM

Posted on by Jodi Snare

Page last updated June 06, 2026

ClinicalTrials.gov#: NCT07358559
Study Design: Other
PCORnet Infrastructure: Single IRB, Patient partners or engagement
Principal Investigator: Virginia A. Brown
Institution: The Hastings Center for Bioethics
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2024
Study Duration: 2025 - 2028
Participating PCORnet® Clinical Research Networks: ADVANCE, GPC, INSIGHT, PaTH, REACHnet, STAR
Therapeutic Area: Engagement Methods
Status: Recruiting

Research Question(s): Do individuals' beliefs about the trustworthiness of a university and other research organizations (e.g., academic medical centers) correlate to how much they trust researchers they partner with on research projects?

Greenlight Plus Study: A Randomized Study of Approaches to Early Childhood Obesity Prevention (Phase 2)

Posted on by Jodi Snare

Page last updated November 9, 2026

Study Website: https://www.greenlight-program.org/
ClinicalTrials.gov#: NCT04042467
Study Design: Intervention Trial
PCORnet Infrastructure (Phase 2): Single IRB, Patient partners or engagement
Principal Investigator: Bill Heerman
Institution: Vanderbilt University Medical Center
PCORnet® Network Partner: STAR
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date (Phase 2): 2025
Study Duration (Phase 2): 2025 - 2031
Participating PCORnet® Clinical Research Networks: INSIGHT, OneFlorida+, PaTH, STAR
Therapeutic Area: Metabolic Disorders
Condition: Behavior, Health; Child Obesity
Status (Phase 2): Recruiting

Research Question(s):
The research team is recruiting 900 English- and Spanish-speaking parent-infant pairs from six primary care clinics. The team is assigning the pairs by chance to receive either Greenlight or Greenlight Plus for two years. At the start of the study and throughout the child's first two years of life, the team is interviewing families and reviewing medical records to see how each baby is growing. The team wants to know how Greenlight and Greenlight Plus compare in promoting healthy weight gain for different groups based on language, race, ethnicity, and health literacy.

The Dose Trial: Dose Intensity of Behavioral Interventions for Childhood Obesity

Posted on by Jodi Snare

Page last updated July 9, 2026

ClinicalTrials.gov#: NCT06654323
Study Design: Intervention Trial
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement, Clinical Research Collaboration Agreement
Principal Investigator: Bill Heerman
Institution: Vanderbilt University Medical Center
PCORnet® Network Partner: STAR
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2024
Study Duration: 2024 – 2030
Participating PCORnet® Clinical Research Networks: REACHnet, STAR
Therapeutic Area: Metabolic Disorders; Other, Pediatric Obesity
Status: Recruiting

Research Question(s):

Can children with obesity achieve meaningful improvements in their health with fewer hours of treatment than currently recommended? This study is testing whether shorter versions of a family-based lifestyle program, delivered through pediatric clinics, are just as effective as the full 26-hour version currently recommended by national guidelines. The goal is to find out if families can benefit from a lower-dose program that is easier to complete, while still helping children improve their weight, quality of life, and health behaviors.

Clinical Outcomes of Medications Post Anti-TNF: Researching Effectiveness in Pediatric IBD

Posted on by Jodi Snare

Page last updated July 09, 2026

Study Design: Prospective Observational Study
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement, Clinical Research Collaboration Agreement
Principal Investigator: Michael D. Kappelman
Institution: University of North Carolina at Chapel Hill
PCORnet® Network Partner: STAR
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2025
Study Duration: 2025 – 2031
Participating PCORnet® Clinical Research Networks: GPC, INSIGHT, OneFlorida+, PEDSnet, PaTH, REACHnet, STAR
Therapeutic Area: Gastroenterology
Status: Recruiting

Research Question(s):

  1. Can we determine which medicine is the safest and most effective at treating kids with Crohn's disease or ulcerative colitis when the first medicine they take does not work for them?

A Comparative Effectiveness Study of Oral Medications Used for Migraine Prevention: The APT Comparison Study

Posted on by Jodi Snare

Page last updated August 28, 2026

Study Design: Intervention Trial
PCORnet Infrastructure: Single IRB, Patient partners or engagement
Principal Investigator: Todd Schwedt
Institution: Mayo Clinic
PCORnet® Network Partner: STAR
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2024
Study Duration: 2025 – 2029
Participating PCORnet® Clinical Research Networks: GPC, One Florida+, PaTH, STAR
Therapeutic Area: Neurology
Status: Recruiting

Research Question(s):

Is a newer oral migraine preventive medication (atogepant) more effective for treating migraines than two older medications (propranolol, topiramate), each of which is commonly used in clinical practice and has strong levels of evidence supporting their efficacy?

Comparative Effectiveness of Carvedilol versus Metoprolol Succinate in Heart Failure Patients with an Implantable Cardioverter Defibrillator

Posted on by Jodi Snare

Page last updated August 22, 2025

ClinicalTrials.gov#: NCT06964464
Study Design: Intervention Trial
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement
Principal Investigator: Mehmet Aktas
Institution: University of Rochester
PCORnet® Network Partner: External
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2024
Study Duration: 2025 – 2031
Participating PCORnet® Clinical Research Networks: GPC, INSIGHT, PaTH, REACHnet
Therapeutic Area: Cardiovascular
Status: Recruiting

Research Question(s):
In this study, we are comparing two commonly used beta-blockers-carvedilol and metoprolol succinate-in people who have heart failure and an implanted defibrillator. We want to find out if carvedilol is more effective than metoprolol succinate at preventing dangerous heart rhythm problems, hospitalizations for heart issues, and deaths caused by heart disease.