PCORnet® Studies
Designating your project as a PCORnet® Study opens the door to enhanced visibility, expert support, validated tools, and integrated patient partnership. It’s a strategic path to maximizing impact and accelerating the translation of your research into real-world benefits.
PCORnet® Studies are national in scope,
- include patient engagement throughout the project lifecycle,
- are committed to broad dissemination of findings,
- leverage PCORnet resources to improve the efficiency of patient-centered research (e.g., the PCORnet® Common Data Model (CDM), single IRB, engagement resources, data sharing agreements, etc.), and
- help build learning systems by sharing progress and lessons learned.
Research Made Easier
Learn about resources offered to researchers interested in using the PCORnet infrastructure.
Study Data Current as of May 8, 2026.
Search all PCORnet® Studies below, filtering by Status, Funder or Therapeutic Area, or search by keyword.
See PCORnet® Study primary results publications here.
Research Question(s): Nerve damage from diabetes (diabetic neuropathy) is a common condition that causes constant, life-disrupting pain for many people. This study will help determine:
- The best initial modality (oral, topical, or behavioral) for painful diabetic neuropathy, and
- whether to switch modalities or stay in those that fail.
Research Question(s): Are non-stimulants equally appropriate first line medications as stimulants for treating ADHD in school age youth, and which youth are most likely to benefit from which approach? This question addresses a health care challenge relevant to all youth with ADHD, their prescribers, and their parents.
Research Question(s): Which children benefit from which treatment for sinus and ear infections?
Research Question(s): Do individuals' beliefs about the trustworthiness of a university and other research organizations (e.g., academic medical centers) correlate to how much they trust researchers they partner with on research projects?
Research Question(s):
Oregon implemented new Medicaid policies intended to increase referrals to connect patients endorsing specific social risks with local non-medical services.
- How do Oregon's new Medicaid policies impact rates of screening, referrals, and receipt of services for social needs?
- Do these policies decrease the difference in rates of screening, referrals, and receipt of services between various demographic groups?
- How do screening, referrals, and receipt of services for social needs impact chronic disease outcome and healthcare utilization? Is the impact different for various demographic groups?
Research Question(s):
The study focuses on making autism research more reliable and widely applicable. We are creating the Autism Replication, Validation, and Reproducibility (AR²) Center to ensure that findings from autism data science projects can be independently verified and reproduced by providing complete, transparent packages, including data, code, and documentation.
By using diverse datasets from across the U.S., we aim to confirm that research results hold true for different populations and settings. This effort will promote best practices, share resources openly, and help translate autism research into real-world clinical care and policy.
Research Question(s): For children hospitalized with pneumonia, skin infections, or urinary infections, do they recover better and have fewer side effects with a 5-day course of antibiotics, or a 10-day course of antibiotics?
Research Question(s): 1) In hospitalized patients with severe infections, does the antibiotic combination workhorse, vancomycin and piperacillin/tazobactam (VPT), cause more kidney injury than another standard antibiotic combination, vancomycin and meropenem (VM), and 2) what is VPT's relative impact on other patient centric outcomes such as mortality, other kidney effects, hospital length of stay, readmissions, complications, and quality of life.
Research Question(s): Can children with obesity achieve meaningful improvements in their health with fewer hours of treatment than currently recommended?
Research Question(s): Can we determine which medicine is the safest and most effective at treating kids with Crohn's disease or ulcerative colitis when the first medicine they take does not work for them?
Research Question(s):
How can we use nationally distributed healthcare data infrastructure to (1) improve the capacity of data and information systems to conduct monitoring and surveillance and (2) increase the capability to use data to inform public health decision-making and support evidence-based practices and policies?
Research Question(s): Does access to new, text messaging-based communications tools help teenagers and adults with IBD (Crohn's Disease and Ulcerative Colitis) feel better able to manage their condition?
Research Question(s): Is a newer oral migraine preventive medication (atogepant) more effective for treating migraines than two older medications (propranolol, topiramate), each of which is commonly used in clinical practice and has strong levels of evidence supporting their efficacy?
Research Question(s): How does the quality of asthma care - including timely diagnosis, assessment, immunization, medication prescription, and access to testing - vary when comparing Latino adults to non-Latino white adults?
Among adults with asthma, how do Latino adults vary from non-Latino white adults in how they utilize primary asthma care in Community Health Centers?
Research Question(s): Do smaller breathing tubes prevent long-term problems with breathing, speaking and swallowing?
Are smaller breathing tubes as good as larger breathing tubes for getting patients through their illness and off the breathing machine?
Research Question(s): In this study, we are comparing two commonly used beta-blockers-carvedilol and metoprolol succinate-in people who have heart failure and an implanted defibrillator. We want to find out if carvedilol is more effective than metoprolol succinate at preventing dangerous heart rhythm problems, hospitalizations for heart issues, and deaths caused by heart disease.
Research Question(s):
Is implantable cardioverter-defibrillator beneficial in eligible heart failure patients with low arrhythmia risk?
Research Question(s): IRIS-CKD is a project focused on improving how doctors check for and treat chronic kidney disease (CKD) in people with type 2 diabetes (T2D). The main goals of the project are to increase the number of people with type 2 diabetes who get screened for chronic kidney disease, and ensure that more patients with both chronic kidney disease and type 2 diabetes receive the treatments recommended by medical guidelines.
Research Question(s):
1) What are the engagement strategies needed for individuals living with NDD and CHD?
2) What metrics (such as surveys, focus groups, etc.) can be employed to measure engagement in individuals living with NDD?
1) What are the engagement strategies needed for individuals living with NDD and CHD?
2) What metrics (such as surveys, focus groups, etc.) can be employed to measure engagement in individuals living with NDD?
Research Question(s): Can a data resource be created to strengthen urinary stone disease research that will generate new knowledge that improves the health of all individuals with urinary stone disease?
Research Question(s): Can we develop a consensus-based strategy that comprehensively measures TTP-associated cognitive function impacts from the patient perspective?
Research Question(s): Can large language models - an advanced form of artificial intelligence (AI) - improve the generalizability of patient information extraction and clinical phenotyping across different healthcare systems?
Research Question(s):
What is the best way to encourage ICU clinicians to consistently and completely implement the ABCDEF Bundle in their care of mechanically ventilated patients?
Research Question(s): For adults 50 and older who have had a recent fracture, can a Fracture Liaison Service that includes a patient navigator, access to a bone health provider, and increased use of bone-strengthen medications help prevent future fractures and improve quality of life?
Research Question(s): Can we identify optimal immunosuppression management strategies for kidney transplant patients leveraging real world data?
Research Question(s): Can we improve the testing and treatment of high cholesterol in patients who have been hospitalized for a cardiac event by providing education to doctors and patients?
Research Question(s):
How can we measure the process of co-creation in a way that is pragmatic, valid, reliable, and associated with meaningful engagement outcomes?
Research Question(s): In this study, the research team wanted to learn if taking HCQ was safe and prevented COVID-19 in healthcare workers.
Research Question(s): The study will answer important questions patients are asking about the link between diabetes and COVID-19.
To what extent does COVID-19 cause worse glycemic control, vascular function, inflammation, and increased risk for blood clots in people with either type 1 or type 2 diabetes?
The study will also explore the role of genomic, social, and environmental factors on metabolic function and the impact of COVID-19 infection and COVID-19 treatments on diabetes-related outcomes.
Research Question(s):
- Did a community rise in COVID-19 hospitalizations and deaths contribute to an increase in the risk of overdose among PCORnet patients?
- What role did public health and economic policies enacted during the COVID-19 pandemic play in explaining whether a rise in community COVID-19 burden contributed to a rise in overdose?
- Did the impact of the COVID-19 pandemic on overdose depend on the socioeconomic, social, and policy characteristics the community had in place prior to the pandemic?