Mental and Behavioral Health

Comparing Alternative Strategies for Pharmacologic Management of Attention-Deficit / Hyperactivity Disorder in Children and Adolescents

Posted on by Jodi Snare

Page last updated April 14, 2026

Study Design: Intervention Trial
Principal Investigator: Stephen Faraone
Institution: The Research Foundation For The State University of New York
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Participating PCORnet® Clinical Research Networks: GPC, INSIGHT, PEDSnet
Therapeutic Area: Mental and Behavioral Health
Status: Not yet recruiting

Research Question(s):

Are non-stimulants equally appropriate first line medications as stimulants for treating ADHD in school age youth, and which youth are most likely to benefit from which approach? This question addresses a health care challenge relevant to all youth with ADHD, their prescribers, and their parents.

Cognitive Behavioral Therapy and Real-Time Pain Management Intervention for Sickle Cell via Mobile Applications (CaRISMA)

Posted on by Jodi Snare

Page last updated October 29, 2025

Study Website: CaRISMA
ClinicalTrials.gov#: NCT04419168
Study Design: Intervention Trial
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement
Principal Investigator: Charles Jonassaint
Institution: University of Pittsburgh
PCORnet® Network Partner: PaTH
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2020
Study Duration: 2020 – 2024
Participating PCORnet® Clinical Research Networks: PaTH, STAR
Therapeutic Area: Mental and Behavioral Health
Condition: Chronic Pain; Depression; Anxiety; Opioid Use
Age Range: 18 Years and older (Adult, Older Adult)
Status: Completed

Research Question(s):
Does mobile phone-delivered computerized cognitive behavioral therapy provide a greater benefit for daily pain and depression in adult patients with sickle cell disease than digital education?

Primary Publications(s):

Badawy SM, Abebe KZ, Reichman CA, et al. Comparing the effectiveness of education versus digital cognitive behavioral therapy for adults with sickle cell disease: protocol for the cognitive behavioral therapy and real-time pain management intervention for sickle cell via mobile applications (CaRISMA) study. JMIR Res Protoc, 2021; 10(5):e29014. doi:10.2196/29014