Studies

Alternative Approaches for Managing Blood Pressure in Children with Chronic Kidney Disease

Posted on by Jodi Snare

Page last updated July 09, 2026

Study Design: Intervention Trial
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement, Clinical Research
Collaboration Agreement
Principal Investigator: Michelle Denburg
Institution: The Children’s Hospital of Philadelphia
PCORnet® Network Partner: PEDSnet
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2026
Study Duration: 2026 – 2031
Participating PCORnet® Clinical Research Networks: GPC, INSIGHT, OneFlorida+, PEDSnet, PaTH, REACHnet, STAR
Therapeutic Area: Nephrology, Rare Diseases
Status: Not yet recruiting

Research Question(s):

1) What blood pressure threshold should be targeted for kidney and cardiovascular protection in children with CKD?

2) Should RAASi be first-line anti-hypertensive therapy for all children with CKD?

Comparative Effectiveness of Different Techniques for Repeat Ablation After Failed Initial Ablation for Persistent Atrial Fibrillation

Posted on by Jodi Snare

Page last updated July 09, 2026

ClinicalTrials.gov#: NCT06988202
Study Design: Intervention Trial
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement
Principal Investigator: Jonathan Steinberg
Institution: University of Rochester
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2025
Study Duration: 2025 – 2031
Participating PCORnet® Clinical Research Networks: STAR
Therapeutic Area: Cardiovascular, Engagement Methods, Healthcare Delivery, Health Disparities
Status: Recruiting

Research Question(s):

Many people with persistent atrial fibrillation have symptoms that continue or return after their first ablation procedure. When this happens, patients and doctors often consider a second ablation. However, there is not enough evidence to know which repeat ablation approach gives patients the best chance of feeling better and reducing future AF-related care.

REPEAT-AF asks whether adding left atrial posterior wall isolation to a repeat pulmonary vein isolation procedure improves symptoms, reduces atrial fibrillation recurrence, lowers AF burden, and reduces cardiovascular-related healthcare use compared with repeat pulmonary vein isolation alone. In plain language, the study asks: For adults who still have atrial fibrillation after a first ablation for persistent AF, does a more comprehensive repeat ablation help patients feel better and have fewer AF-related problems than the standard repeat ablation approach?

Modality Choice Before and After Failure for the Treatment of Painful Diabetic Neuropathy

Posted on by Jodi Snare

Page last updated July 09, 2026

Study Design: Intervention Trial
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement, Clinical Research Collaboration Agreement
Principal Investigator: Brian Callaghan
Institution: University of Michigan
PCORnet® Network Partner: PaTH
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2026
Study Duration: 2026 – 2031
Participating PCORnet® Clinical Research Networks: ADVANCE, GPC, INSIGHT, OneFlorida+, PaTH, REACHnet, STAR
Therapeutic Area: Neurology, Endocrinology
Status: Not yet recruiting

Research Question(s):

Nerve damage from diabetes (diabetic neuropathy) is a common condition that causes constant, life-disrupting pain for many people. This study will help determine:

  1. The best initial modality (oral, topical, or behavioral) for painful diabetic neuropathy, and
  2. whether to switch modalities or stay in those that fail.

Finding these answers is vital for helping people manage pain without relying on opioids and to let patients and doctors choose the treatments they prefer to ensure the focus is on what actually matters most to those living with this condition.

Comparing Alternative Strategies for Pharmacologic Management of Attention-Deficit / Hyperactivity Disorder in Children and Adolescents

Posted on by Jodi Snare

Page last updated May 11, 2026

Study Design: Intervention Trial
Principal Investigator: Stephen Faraone
Institution: The Research Foundation For The State University of New York
PCORnet® Network Partner: INSIGHT
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Participating PCORnet® Clinical Research Networks: GPC, INSIGHT, PEDSnet
Therapeutic Area: Mental and Behavioral Health
Status: Not yet recruiting

Research Question(s):

Are non-stimulants equally appropriate first line medications as stimulants for treating ADHD in school age youth, and which youth are most likely to benefit from which approach? This question addresses a health care challenge relevant to all youth with ADHD, their prescribers, and their parents.

Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children: Which Children Benefit from Which Treatment? (MEASURE Trial)

Posted on by Jodi Snare

Page last updated June 06, 2026

Study Design: Intervention Trial
PCORnet Infrastructure: Single IRB, Patient partners or engagement, Clinical Research Collaboration Agreement
Principal Investigator: Nader Shaikh
Institution: University of Pittsburgh
PCORnet® Network Partner: PaTH
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2025
Study Duration: 2026 - 2032
Participating PCORnet® Clinical Research Networks: GPC, PaTH, PEDSnet, STAR
Therapeutic Area: Infectious Disease
Status: Not yet recruiting

Research Question(s): Which children benefit from which treatment for sinus and ear infections?

Teaming Researchers Up with Stakeholders to Test Trustworthy Engagement and Measure: TRUST TEAM

Posted on by Jodi Snare

Page last updated June 06, 2026

ClinicalTrials.gov#: NCT07358559
Study Design: Other
PCORnet Infrastructure: Single IRB, Patient partners or engagement
Principal Investigator: Virginia A. Brown
Institution: The Hastings Center for Bioethics
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2024
Study Duration: 2025 - 2028
Participating PCORnet® Clinical Research Networks: ADVANCE, GPC, INSIGHT, PaTH, REACHnet, STAR
Therapeutic Area: Engagement Methods
Status: Recruiting

Research Question(s): Do individuals' beliefs about the trustworthiness of a university and other research organizations (e.g., academic medical centers) correlate to how much they trust researchers they partner with on research projects?

Oregon Medicaid Policy, Social Services, and Health (RESOLVE)

Posted on by Jodi Snare

Page last updated June 06, 2026

Study Design: Other
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement
Principal Investigator: Caroline Fichtenberg and Danielle Hessler Jones
Institution: University of California, San Francisco
PCORnet® Network Partner: REACHnet
Funder: Federal (NIH)
Funding Date: 2024
Study Duration: 2024 – 2029
Participating PCORnet® Clinical Research Networks: ADVANCE, REACHnet
Therapeutic Area: Healthcare Delivery, Cardiovascular, Endocrinology, Healthcare Delivery, Health Disparities, Mental and Behavioral Health, Other
Status: Active, not recruiting

Research Question(s):

Oregon implemented new Medicaid policies intended to increase referrals to connect patients endorsing specific social risks with local non-medical services.

  1. How do Oregon's new Medicaid policies impact rates of screening, referrals, and receipt of services for
    social needs?
  2. Do these policies decrease the difference in rates of screening, referrals, and receipt of services between various demographic groups?
  3. How do screening, referrals, and receipt of services for social needs impact chronic disease outcome and
    healthcare utilization? Is the impact different for various demographic groups?

AR² – Autism Replication, Validation, and Reproducibility Center

Posted on by Jodi Snare

Page last updated May 11, 2026

Study Design: Retrospective Observational Trial
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement
Principal Investigator: Judy Zhong
Institution: Weill Cornell Medicine
PCORnet® Network Partner: INSIGHT
Funder: Federal (NIH)
Funding Date: 2025
Study Duration: 2025 – 2028
Participating PCORnet® Clinical Research Networks: ADVANCE, GPC, INSIGHT, PEDSnet, STAR
Therapeutic Area: Intellectual and Developmental Disabilities (IDDs); Data Science
Status: Active, not recruiting

Research Question(s):

The study focuses on making autism research more reliable and widely applicable. We are creating the Autism Replication, Validation, and Reproducibility (AR²) Center to ensure that findings from autism data science projects can be independently verified and reproduced by providing complete, transparent packages, including data, code, and documentation.

By using diverse datasets from across the U.S., we aim to confirm that research results hold true for different populations and settings. This effort will promote best practices, share resources openly, and help translate autism research into real-world clinical care and policy.

Comparing Two Durations of Antibiotic Treatment for Children Hospitalized with Common Infections

Posted on by Jodi Snare

Page last updated March 12, 2026

Study Design: Intervention Trial
PCORnet Infrastructure: Single IRB, Patient partners or engagement
Principal Investigator: Sunitha Kaiser and Katherine Auger
Institution: University of California, San Francisco
PCORnet® Network Partner: REACHnet
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2025
Study Duration: 2025 – 2032
Participating PCORnet® Clinical Research Networks: GPC, OneFlorida+, PaTH, PEDSnet, REACHnet, STAR
Therapeutic Area: Infectious Disease
Status: Enrolling by invitation

Research Question(s):
For children hospitalized with pneumonia, skin infections, or urinary infections, do they recover better and have fewer side effects with a 5-day course of antibiotics, or a 10-day course of antibiotics?

A Randomized Controlled Trial Comparing Renal Effects of Vancomycin Combined With Either Piperacillin/tazobactam or Meropenem

Posted on by Jodi Snare

Page last updated February 4, 2026

Study Design: Intervention Trial
PCORnet Infrastructure: Single IRB, Patient partners or engagement, Clinical Research Collaboration Agreement
Principal Investigator: Daniel Freilich
Institution: Other
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2025
Study Duration: 2026 – 2029
Participating PCORnet® Clinical Research Networks: ADVANCE, GPC, INSIGHT, OneFlorida+, PaTH, REACHnet, STAR
Therapeutic Area: Infectious Disease; Nephrology
Status: Not yet recruiting

Research Question(s): 1) In hospitalized patients with severe infections, does the antibiotic combination workhorse, vancomycin and piperacillin/tazobactam (VPT), cause more kidney injury than another standard antibiotic combination, vancomycin and meropenem (VM), and 2) what is VPT's relative impact on other patient centric outcomes such as mortality, other kidney effects, hospital length of stay, readmissions, complications, and quality of life.