Studies

Modality choice before and after failure for the treatment of painful diabetic neuropathy

Posted on by Jodi Snare

Page last updated May 11, 2026

Study Design: Intervention Trial
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement, Clinical Research Collaboration Agreement
Principal Investigator: Brian Callaghan
Institution: University of Michigan
PCORnet® Network Partner: PaTH
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2026
Study Duration: 2026 – 2031
Participating PCORnet® Clinical Research Networks: PaTH
Therapeutic Area: Neurology, Endocrinology
Status: Unknown

Research Question(s):

Nerve damage from diabetes (diabetic neuropathy) is a common condition that causes constant, life-disrupting pain for many people. This study will help determine:

  1. The best initial modality (oral, topical, or behavioral) for painful diabetic neuropathy, and
  2. whether to switch modalities or stay in those that fail.

Finding these answers is vital for helping people manage pain without relying on opioids and to let patients and doctors choose the treatments they prefer to ensure the focus is on what actually matters most to those living with this condition.

Comparing Alternative Strategies for Pharmacologic Management of Attention-Deficit / Hyperactivity Disorder in Children and Adolescents

Posted on by Jodi Snare

Page last updated May 11, 2026

Study Design: Intervention Trial
Principal Investigator: Stephen Faraone
Institution: The Research Foundation For The State University of New York
PCORnet® Network Partner: INSIGHT
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Participating PCORnet® Clinical Research Networks: GPC, INSIGHT, PEDSnet
Therapeutic Area: Mental and Behavioral Health
Status: Not yet recruiting

Research Question(s):

Are non-stimulants equally appropriate first line medications as stimulants for treating ADHD in school age youth, and which youth are most likely to benefit from which approach? This question addresses a health care challenge relevant to all youth with ADHD, their prescribers, and their parents.

Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children: Which Children Benefit from Which Treatment? (MEASURE Trial)

Posted on by Jodi Snare

Page last updated March 12, 2026

Study Design: Intervention Trial
PCORnet Infrastructure: Single IRB, Patient partners or engagement, Clinical Research Collaboration Agreement
Principal Investigator: Nader Shaikh
Institution: University of Pittsburgh
PCORnet® Network Partner: PaTH
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2025
Study Duration: 2026 – 2032
Therapeutic Area: Infectious Disease
Status: Unknown Status

Research Question(s): Which children benefit from which treatment for sinus and ear infections?

Teaming Researchers Up with Stakeholders to Test Trustworthy Engagement and Measure: TRUST TEAM

Posted on by Jodi Snare

Page last updated May 11, 2026

ClinicalTrials.gov#: NCT07358559
Study Design: Other
PCORnet Infrastructure: Single IRB, Patient partners or engagement
Principal Investigator: Virginia A. Brown
Institution: The Hastings Center for Bioethics
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2024
Study Duration: 2025 - 2028
Therapeutic Area: Engagement Methods
Status: Not yet recruiting

Research Question(s): Do individuals' beliefs about the trustworthiness of a university and other research organizations (e.g., academic medical centers) correlate to how much they trust researchers they partner with on research projects?

Oregon Medicaid Policy, Social Services, and Health (RESOLVE)

Posted on by Jodi Snare

Page last updated May 11, 2026

Study Design: Other
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement
Principal Investigator: Caroline Fichtenberg and Danielle Hessler Jones
Institution: University of California, San Francisco
PCORnet® Network Partner: ADVANCE
Funder: Federal (NIH)
Funding Date: 2024
Study Duration: 2024 – 2029
Participating PCORnet® Clinical Research Networks: ADVANCE, REACHnet
Therapeutic Area: Healthcare Delivery
Status: Active, not recruiting

Research Question(s):

Oregon implemented new Medicaid policies intended to increase referrals to connect patients endorsing specific social risks with local non-medical services.

  1. How do Oregon's new Medicaid policies impact rates of screening, referrals, and receipt of services for
    social needs?
  2. Do these policies decrease the difference in rates of screening, referrals, and receipt of services between various demographic groups?
  3. How do screening, referrals, and receipt of services for social needs impact chronic disease outcome and
    healthcare utilization? Is the impact different for various demographic groups?

AR² – Autism Replication, Validation, and Reproducibility Center

Posted on by Jodi Snare

Page last updated May 11, 2026

Study Design: Retrospective Observational Trial
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement
Principal Investigator: Judy Zhong
Institution: Weill Cornell Medicine
PCORnet® Network Partner: INSIGHT
Funder: Federal (NIH)
Funding Date: 2025
Study Duration: 2025 – 2028
Participating PCORnet® Clinical Research Networks: ADVANCE, GPC, INSIGHT, PEDSnet, STAR
Therapeutic Area: Intellectual and Developmental Disabilities (IDDs); Data Science
Status: Active, not recruiting

Research Question(s):

The study focuses on making autism research more reliable and widely applicable. We are creating the Autism Replication, Validation, and Reproducibility (AR²) Center to ensure that findings from autism data science projects can be independently verified and reproduced by providing complete, transparent packages, including data, code, and documentation.

By using diverse datasets from across the U.S., we aim to confirm that research results hold true for different populations and settings. This effort will promote best practices, share resources openly, and help translate autism research into real-world clinical care and policy.

Comparing Two Durations of Antibiotic Treatment for Children Hospitalized with Common Infections

Posted on by Jodi Snare

Page last updated March 12, 2026

Study Design: Intervention Trial
PCORnet Infrastructure: Single IRB, Patient partners or engagement
Principal Investigator: Sunitha Kaiser and Katherine Auger
Institution: University of California, San Francisco
PCORnet® Network Partner: REACHnet
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2025
Study Duration: 2025 – 2032
Participating PCORnet® Clinical Research Networks: GPC, OneFlorida+, PaTH, PEDSnet, REACHnet, STAR
Therapeutic Area: Infectious Disease
Status: Enrolling by invitation

Research Question(s):
For children hospitalized with pneumonia, skin infections, or urinary infections, do they recover better and have fewer side effects with a 5-day course of antibiotics, or a 10-day course of antibiotics?

A Randomized Controlled Trial Comparing Renal Effects of Vancomycin Combined With Either Piperacillin/tazobactam or Meropenem

Posted on by Jodi Snare

Page last updated February 4, 2026

Study Design: Intervention Trial
PCORnet Infrastructure: Single IRB, Patient partners or engagement, Clinical Research Collaboration Agreement
Principal Investigator: Daniel Freilich
Institution: Other
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2025
Study Duration: 2026 – 2029
Participating PCORnet® Clinical Research Networks: ADVANCE, GPC, INSIGHT, OneFlorida+, PaTH, REACHnet, STAR
Therapeutic Area: Infectious Disease; Nephrology
Status: Not yet recruiting

Research Question(s): 1) In hospitalized patients with severe infections, does the antibiotic combination workhorse, vancomycin and piperacillin/tazobactam (VPT), cause more kidney injury than another standard antibiotic combination, vancomycin and meropenem (VM), and 2) what is VPT's relative impact on other patient centric outcomes such as mortality, other kidney effects, hospital length of stay, readmissions, complications, and quality of life.

The Dose Trial: Dose Intensity of Behavioral Interventions for Childhood Obesity

Posted on by Jodi Snare

Page last updated May 11, 2026

ClinicalTrials.gov#: NCT06654323
Study Design: Intervention Trial
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement, Clinical Research Collaboration Agreement
Principal Investigator: Bill Heerman
Institution: Vanderbilt University Medical Center
PCORnet® Network Partner: STAR
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2024
Study Duration: 2024 – 2030
Participating PCORnet® Clinical Research Networks: STAR
Therapeutic Area: Metabolic Disorders; Other, Pediatric Obesity
Status: Recruiting

Research Question(s):

Can children with obesity achieve meaningful improvements in their health with fewer hours of treatment than currently recommended? This study is testing whether shorter versions of a family-based lifestyle program, delivered through pediatric clinics, are just as effective as the full 26-hour version currently recommended by national guidelines. The goal is to find out if families can benefit from a lower-dose program that is easier to complete, while still helping children improve their weight, quality of life, and health behaviors.

Clinical Outcomes of Medications Post Anti-TNF: Researching Effectiveness in Pediatric IBD

Posted on by Jodi Snare

Page last updated November 12, 2025

Study Design: Prospective Observational Study
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement, Clinical Research Collaboration Agreement
Principal Investigator: Michael D. Kappelman
Institution: University of North Carolina at Chapel Hill
PCORnet® Network Partner: STAR
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2025
Study Duration: 2025 – 2031
Participating PCORnet® Clinical Research Networks: GPC, INSIGHT, OneFlorida+, PaTH, PEDSnet, REACHnet, STAR
Therapeutic Area: Gastroenterology
Status: Not yet recruiting

Research Question(s):

  1. Can we determine which medicine is the safest and most effective at treating kids with Crohn's disease or ulcerative colitis when the first medicine they take does not work for them?