Page last updated May 11, 2026
Study Design: Intervention Trial
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement, Clinical Research Collaboration Agreement
Principal Investigator: Brian Callaghan
Institution: University of Michigan
PCORnet® Network Partner: PaTH
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2026
Study Duration: 2026 – 2031
Participating PCORnet® Clinical Research Networks: PaTH
Therapeutic Area: Neurology, Endocrinology
Status: Unknown
Research Question(s):
Nerve damage from diabetes (diabetic neuropathy) is a common condition that causes constant, life-disrupting pain for many people. This study will help determine:
- The best initial modality (oral, topical, or behavioral) for painful diabetic neuropathy, and
- whether to switch modalities or stay in those that fail.
Finding these answers is vital for helping people manage pain without relying on opioids and to let patients and doctors choose the treatments they prefer to ensure the focus is on what actually matters most to those living with this condition.