Intervention

Community Health Workers Systematically Assessing and Addressing Social Determinants of Health to Improve Outcomes in Community Health Centers (CHW-SYSTIM)

Posted on by Jodi Snare

Page last updated August 6, 2026

ClinicalTrials.gov#: NCT06926855
Study Design: Intervention Trial
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement
Principal Investigator: Rachel Gold and Erika Cottrell
Institution: OCHIN
PCORnet® Network Partner: ADVANCE
Funder: Federal (NIH/National Heart, Lung, and Blood Institute (NHLBI))
Funding Date: 2023
Study Duration: 2024 – 2026
Therapeutic Area: Healthcare Delivery, Cardiovascular, Health Disparities, Metabolic Disorders
Status: Completed

Research Question(s):

Community health workers (CHWs) often provide patient education and care coordination in community health center (CHC) settings. CHWs have unique skill sets to support patient education, connect patients with resources, and understand patient needs in the context of their culture and community. Both CHCs and CHWs are recognized as valuable research partners because of the trust and knowledge they hold with the patient populations they serve. This study asked if CHWs can help improve health for people with diabetes or high blood pressure by asking about and helping to address their social needs. CHWs asked people about needs related to food, housing, transportation, or medications and then helped to connect them with available services based on each patient’s given needs. CHWs then followed-up with each patient to see if they connected with any resources.

Detection of Elder Abuse Through Emergency Care Technicians – Revised for Primary Care

Posted on by Jodi Snare

Page last updated August 6, 2026

ClinicalTrials.gov#: NCT05958654
Study Design: Intervention Trial
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement
Principal Investigator: Brad Cannell
Institution: University of Texas Health Science Center at Houston
Funder: Federal (NIH/NIA)
Funding Date: 2022
Study Duration: 2022 – 2028
Participating PCORnet® Clinical Research Networks: GPC, OneFlorida+, PaTH, REACHnet
Therapeutic Area: Healthcare Delivery, Data Science, Mental and Behavioral Health, Neurology
Status: Active, not recruiting

Research Question(s):

Can a structured screening and reporting program — used by home-based primary care clinicians during routine visits — help identify older adults who may be experiencing abuse, neglect, or financial exploitation, particularly those living with dementia, and connect them with needed services and supports?

Primary Publication(s):

Cannell B, Sevey N, Livingston MD, Burnett J, Lees Haggerty K, Pickering C. Detection of Elder Abuse Through Emergency Care Technicians Screening Tool Revision for Home-Based Primary Care (DETECT-RPC): a cluster randomised controlled trial study protocol. BMJ Open. 2025;15(1):e089028. doi:10.1136/bmjopen-2024-089028

Lees Haggerty K, Campetti R, Ojelabi O, et al. Adaptation of DETECT for use in home-based primary care: Clinician perspectives. J Am Geriatr Soc. 2026;74(5):1421-1428. doi:10.1111/jgs.70296

Observational Approach versus Surgical Intervention for Stones

Posted on by Jodi Snare

Page last updated August 5, 2026

ClinicalTrials.gov#: NCT07718802
Study Design: Intervention Trial
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement, Clinical Research
Collaboration Agreement
Principal Investigator: Gregory Tasian
Institution: The Children’s Hospital of Philadelphia
PCORnet® Network Partner: PEDSnet
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2026
Study Duration: 2026 – 2031
Participating PCORnet® Clinical Research Networks: ADVANCE, GPC, INSIGHT, OneFlorida+, PaTH, PEDSnet, REACHnet, STAR
Therapeutic Area: Nephrology
Status: Not yet recruiting

Research Question(s):

Whether observation or upfront surgery results in less life disruption from asymptomatic (showing no symptoms) kidney stones for children and adults.

Alternative Approaches for Managing Blood Pressure in Children with Chronic Kidney Disease

Posted on by Jodi Snare

Page last updated July 09, 2026

Study Design: Intervention Trial
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement, Clinical Research
Collaboration Agreement
Principal Investigator: Michelle Denburg
Institution: The Children’s Hospital of Philadelphia
PCORnet® Network Partner: PEDSnet
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2026
Study Duration: 2026 – 2031
Participating PCORnet® Clinical Research Networks: GPC, INSIGHT, OneFlorida+, PEDSnet, PaTH, REACHnet, STAR
Therapeutic Area: Nephrology, Rare Diseases
Status: Not yet recruiting

Research Question(s):

1) What blood pressure threshold should be targeted for kidney and cardiovascular protection in children with CKD?

2) Should RAASi be first-line anti-hypertensive therapy for all children with CKD?

Comparative Effectiveness of Different Techniques for Repeat Ablation After Failed Initial Ablation for Persistent Atrial Fibrillation

Posted on by Jodi Snare

Page last updated August 06, 2026

ClinicalTrials.gov#: NCT06988202
Study Design: Intervention Trial
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement
Principal Investigator: Jonathan Steinberg
Institution: University of Rochester
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2025
Study Duration: 2025 – 2031
Participating PCORnet® Clinical Research Networks: GPC, PaTH, STAR
Therapeutic Area: Cardiovascular, Engagement Methods, Healthcare Delivery, Health Disparities
Status: Recruiting

Research Question(s):

Many people with persistent atrial fibrillation have symptoms that continue or return after their first ablation procedure. When this happens, patients and doctors often consider a second ablation. However, there is not enough evidence to know which repeat ablation approach gives patients the best chance of feeling better and reducing future AF-related care.

REPEAT-AF asks whether adding left atrial posterior wall isolation to a repeat pulmonary vein isolation procedure improves symptoms, reduces atrial fibrillation recurrence, lowers AF burden, and reduces cardiovascular-related healthcare use compared with repeat pulmonary vein isolation alone. In plain language, the study asks: For adults who still have atrial fibrillation after a first ablation for persistent AF, does a more comprehensive repeat ablation help patients feel better and have fewer AF-related problems than the standard repeat ablation approach?

Modality Choice Before and After Failure for the Treatment of Painful Diabetic Neuropathy

Posted on by Jodi Snare

Page last updated July 09, 2026

Study Design: Intervention Trial
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement, Clinical Research Collaboration Agreement
Principal Investigator: Brian Callaghan
Institution: University of Michigan
PCORnet® Network Partner: PaTH
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2026
Study Duration: 2026 – 2031
Participating PCORnet® Clinical Research Networks: ADVANCE, GPC, INSIGHT, OneFlorida+, PaTH, REACHnet, STAR
Therapeutic Area: Neurology, Endocrinology
Status: Not yet recruiting

Research Question(s):

Nerve damage from diabetes (diabetic neuropathy) is a common condition that causes constant, life-disrupting pain for many people. This study will help determine:

  1. The best initial modality (oral, topical, or behavioral) for painful diabetic neuropathy, and
  2. whether to switch modalities or stay in those that fail.

Finding these answers is vital for helping people manage pain without relying on opioids and to let patients and doctors choose the treatments they prefer to ensure the focus is on what actually matters most to those living with this condition.

Comparing Alternative Strategies for Pharmacologic Management of Attention-Deficit / Hyperactivity Disorder in Children and Adolescents

Posted on by Jodi Snare

Page last updated August 06, 2026

Study Design: Intervention Trial
Principal Investigator: Stephen Faraone
Institution: Norton College of Medicine at SUNY Upstate Medical University
PCORnet® Network Partner: INSIGHT
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Participating PCORnet® Clinical Research Networks: GPC, INSIGHT, PEDSnet
Therapeutic Area: Mental and Behavioral Health
Status: Not yet recruiting

Research Question(s):

Are non-stimulants equally appropriate first line medications as stimulants for treating ADHD in school age youth, and which youth are most likely to benefit from which approach? This question addresses a health care challenge relevant to all youth with ADHD, their prescribers, and their parents.

Comparative Effectiveness of Available Treatments for Sinus and Ear Infections in Children: Which Children Benefit from Which Treatment? (MEASURE Trial)

Posted on by Jodi Snare

Page last updated June 06, 2026

Study Design: Intervention Trial
PCORnet Infrastructure: Single IRB, Patient partners or engagement, Clinical Research Collaboration Agreement
Principal Investigator: Nader Shaikh
Institution: University of Pittsburgh
PCORnet® Network Partner: PaTH
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2025
Study Duration: 2026 - 2032
Participating PCORnet® Clinical Research Networks: GPC, PaTH, PEDSnet, STAR
Therapeutic Area: Infectious Disease
Status: Not yet recruiting

Research Question(s): Which children benefit from which treatment for sinus and ear infections?

Comparing Two Durations of Antibiotic Treatment for Children Hospitalized with Common Infections

Posted on by Jodi Snare

Page last updated March 12, 2026

Study Design: Intervention Trial
PCORnet Infrastructure: Single IRB, Patient partners or engagement
Principal Investigator: Sunitha Kaiser and Katherine Auger
Institution: University of California, San Francisco
PCORnet® Network Partner: REACHnet
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2025
Study Duration: 2025 – 2032
Participating PCORnet® Clinical Research Networks: GPC, OneFlorida+, PaTH, PEDSnet, REACHnet, STAR
Therapeutic Area: Infectious Disease
Status: Enrolling by invitation

Research Question(s):
For children hospitalized with pneumonia, skin infections, or urinary infections, do they recover better and have fewer side effects with a 5-day course of antibiotics, or a 10-day course of antibiotics?

A Randomized Controlled Trial Comparing Renal Effects of Vancomycin Combined With Either Piperacillin/tazobactam or Meropenem

Posted on by Jodi Snare

Page last updated February 4, 2026

Study Design: Intervention Trial
PCORnet Infrastructure: Single IRB, Patient partners or engagement, Clinical Research Collaboration Agreement
Principal Investigator: Daniel Freilich
Institution: Other
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2025
Study Duration: 2026 – 2029
Participating PCORnet® Clinical Research Networks: ADVANCE, GPC, INSIGHT, OneFlorida+, PaTH, REACHnet, STAR
Therapeutic Area: Infectious Disease; Nephrology
Status: Not yet recruiting

Research Question(s): 1) In hospitalized patients with severe infections, does the antibiotic combination workhorse, vancomycin and piperacillin/tazobactam (VPT), cause more kidney injury than another standard antibiotic combination, vancomycin and meropenem (VM), and 2) what is VPT's relative impact on other patient centric outcomes such as mortality, other kidney effects, hospital length of stay, readmissions, complications, and quality of life.