Studies

The Dose Trial: Dose Intensity of Behavioral Interventions for Childhood Obesity

Posted on by Jodi Snare

Page last updated July 9, 2026

ClinicalTrials.gov#: NCT06654323
Study Design: Intervention Trial
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement, Clinical Research Collaboration Agreement
Principal Investigator: Bill Heerman
Institution: Vanderbilt University Medical Center
PCORnet® Network Partner: STAR
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2024
Study Duration: 2024 – 2030
Participating PCORnet® Clinical Research Networks: REACHnet, STAR
Therapeutic Area: Metabolic Disorders; Other, Pediatric Obesity
Status: Recruiting

Research Question(s):

Can children with obesity achieve meaningful improvements in their health with fewer hours of treatment than currently recommended? This study is testing whether shorter versions of a family-based lifestyle program, delivered through pediatric clinics, are just as effective as the full 26-hour version currently recommended by national guidelines. The goal is to find out if families can benefit from a lower-dose program that is easier to complete, while still helping children improve their weight, quality of life, and health behaviors.

Clinical Outcomes of Medications Post Anti-TNF: Researching Effectiveness in Pediatric IBD

Posted on by Jodi Snare

Page last updated July 09, 2026

Study Design: Prospective Observational Study
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement, Clinical Research Collaboration Agreement
Principal Investigator: Michael D. Kappelman
Institution: University of North Carolina at Chapel Hill
PCORnet® Network Partner: STAR
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2025
Study Duration: 2025 – 2031
Participating PCORnet® Clinical Research Networks: GPC, INSIGHT, OneFlorida+, PEDSnet, PaTH, REACHnet, STAR
Therapeutic Area: Gastroenterology
Status: Recruiting

Research Question(s):

  1. Can we determine which medicine is the safest and most effective at treating kids with Crohn's disease or ulcerative colitis when the first medicine they take does not work for them?

Advancing Public Health Use of Electronic Health Record Data

Posted on by Jodi Snare

Page last updated May 11, 2026

Study Design: Other, Data Science
PCORnet Infrastructure: Common Data Model (CDM), Patient partners or engagement
Principal Investigators: Jason P. Block and Tom Carton
Institution: Other
Funder: Federal (CDC)
Funding Date: 2024
Study Duration: 2024 – 2026
Participating PCORnet® Clinical Research Networks: ADVANCE, GPC, INSIGHT, OneFlorida+, PaTH, PEDSnet, REACHnet, STAR
Therapeutic Area: Infectious Disease
Condition: Other; Public health surveillance across COVID-19, influenza and select chronic diseases and other infectious diseases
Status: Active, not recruiting

Research Question(s):

How can we use nationally distributed healthcare data infrastructure to (1) improve the capacity of data and information systems to conduct monitoring and surveillance and (2) increase the capability to use data to inform public health decision-making and support evidence-based practices and policies?

Primary Publication(s):

Zhang, Y., Romieu-Hernandez, A., Boehmer, T.K. et al. Association between SARS-CoV-2 infection and select symptoms and conditions 31 to 150 days after testing among children and adults. BMC Infect Dis 24, 181 (2024). doi.org/10.1186/s12879-024-09076-8

Jackson SL, Lekiachvili A, Block JP, et al. Preventive Service Usage and New Chronic Disease Diagnoses: Using PCORnet Data to Identify Emerging Trends, United States, 2018-2022. Prev Chronic Dis. 2024 Jul 3;21:E49. doi: 10.5888/pcd21.230415

Ghildayal N, Nagavedu K, Wiltz JL, et al. Public Health Surveillance in Electronic Health Records: Lessons From PCORnet. Prev Chronic Dis. 2024 Jul 11;21:E51. doi: 10.5888/pcd21.230417

Improving Outcomes and Reducing Disparities for Patients With Inflammatory Bowel Disease Through Epidemiology and Enhanced Disease Management (PROMOTE IBD)

Posted on by Jodi Snare

Page last updated May 11, 2026

ClinicalTrials.gov#: NCT06424769
Study Design: Intervention Trial
PCORnet Infrastructure: Single IRB, Patient partners or engagement
Principal Investigator: Michael D. Kappelman
Institution: University of North Carolina at Chapel Hill
PCORnet® Network Partner: STAR
Funder: Federal (CDC)
Funding Date: 2023
Study Duration: 2023 – 2028
Participating PCORnet® Clinical Research Networks: INSIGHT, PaTH, REACHnet, STAR
Therapeutic Area: Gastroenterology
Status: Recruiting

Research Question(s):

  1. Does access to new, text messaging-based communications tools help teenagers and adults with IBD (Crohn's Disease and Ulcerative Colitis) feel better able to manage their condition?

A Comparative Effectiveness Study of Oral Medications Used for Migraine Prevention: The SPT Comparison Study

Posted on by Jodi Snare

Page last updated October 29, 2025

Study Design: Intervention Trial
PCORnet Infrastructure: Single IRB, Patient partners or engagement
Principal Investigator: Todd Schwedt
Institution: Mayo Clinic
PCORnet® Network Partner: STAR
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2024
Study Duration: 2025 – 2029
Participating PCORnet® Clinical Research Networks: GPC, One Florida+, PaTH, STAR
Therapeutic Area: Neurology
Status: Recruiting

Research Question(s):

Is a newer oral migraine preventive medication (atogepant) more effective for treating migraines than two older medications (propranolol, topiramate), each of which is commonly used in clinical practice and has strong levels of evidence supporting their efficacy?

Equity in Treatment for Asthma Between Latinos and Whites

Posted on by Jodi Snare

Page last updated May 11, 2026

Study Design: Retrospective Observational Study
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement
Principal Investigator: John Heintzman
Institution: OCHIN
PCORnet® Network Partner: ADVANCE
Funder: Federal (NIH/NHLBI)
Funding Date: 2025
Study Duration: 2025 – 2028
Participating PCORnet® Clinical Research Networks: ADVANCE, REACHnet
Therapeutic Area: Pulmonology
Status: Active, not recruiting

Research Question(s):

  1. How does the quality of asthma care - including timely diagnosis, assessment, immunization, medication prescription, and access to testing - vary when comparing Latino adults to non-Latino white adults?
  2. Among adults with asthma, how do Latino adults vary from non-Latino white adults in how they utilize primary asthma care in Community Health Centers?
  3. How do Latino and non-Latino white adults with asthma vary in how they utilize acute care, including clinic visits, emergency department visits, and inpatient hospitalization?
  4. Do different subgroups of Latino-Americans, such as Latinos of Mexican, Dominican, or Cuban heritage, utilize asthma care at different rates and receive care of differing quality?
  5. Relatively, do individual factors (e.g., income, preferred language, insurance coverage, and migrant status) or community-level factors (e.g., community poverty, education, and environmental factors) contribute more to a person's (focusing on Latinos, but including others as well) likelihood of receiving primary asthma care, utilizing acute care, or experiencing asthma-related death?

Preserving Kidney Function in Children with Chronic Kidney Disease (PRESERVE)

Posted on by Jodi Snare

Page last updated July 1, 2026

ClinicalTrials.gov#: NCT05169411
Study Design: Retrospective Observational Study
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement
Principal Investigator: Christopher Forrest and Michelle Denburg
Institution: The Children's Hospital of Philadelphia
PCORnet® Network Partner: PEDSnet
Funder: Patient-Centered Outcomes Research Institute (PCORI); (project webpage)
Funding Date: 2021
Study Duration: 2021 – 2024
Participating PCORnet® Clinical Research Networks: GPC, OneFlorida+, PEDSnet, PaTH, STAR
Therapeutic Area: Nephrology, Rare Diseases
Condition: Chronic Kidney Disease Stage 2; Chronic Kidney Disease Stage 3; Pediatric Kidney Disease
Age Range: 1 Year to 17 Years (Child)
Status: Completed

Research Question(s):

  1. Which blood pressure monitoring strategies, urine protein monitoring strategies, and blood pressure medication strategies are most effective in preserving kidney function in pediatric patients with Chronic Kidney Disease (CKD), and what is the lived experience of families and patients living with pediatric CKD?

Primary Publication(s):

Denburg MR, Goodwin Davies AJ, Maltenfort MG, et al. Comparative Effectiveness of Antihypertensive Medications in Children With Chronic Kidney Disease. JAMA Pediatr. 2026;180(5):546–555. doi:10.1001/jamapediatrics.2026.0207

Tube Size Randomized Trial during Emergency Tracheal Intubation

Posted on by Jodi Snare

Page last updated November 07, 2025

Study Design: Intervention Trial
PCORnet Infrastructure: Single IRB, Patient partners or engagement, Clinical Research
Collaboration Agreement
Principal Investigator: Jonathan Casey
Institution: Vanderbilt University Medical Center
PCORnet® Network Partner: STAR
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2024
Study Duration: 2025 – 2029
Participating PCORnet® Clinical Research Networks: ADVANCE, OneFlorida+, STAR
Therapeutic Area: Pulmonology
Status: Enrolling by invitation

Research Question(s):

  1. Do smaller breathing tubes prevent long-term problems with breathing, speaking and swallowing?
  2. Are smaller breathing tubes as good as larger breathing tubes for getting patients through their illness and off the breathing machine?

Comparative Effectiveness of Carvedilol versus Metoprolol Succinate in Heart Failure Patients with an Implantable Cardioverter Defibrillator

Posted on by Jodi Snare

Page last updated August 22, 2025

ClinicalTrials.gov#: NCT06964464
Study Design: Intervention Trial
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement
Principal Investigator: Mehmet Aktas
Institution: University of Rochester
PCORnet® Network Partner: External
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2024
Study Duration: 2025 – 2031
Participating PCORnet® Clinical Research Networks: GPC, INSIGHT, PaTH, REACHnet
Therapeutic Area: Cardiovascular
Status: Recruiting

Research Question(s):
In this study, we are comparing two commonly used beta-blockers-carvedilol and metoprolol succinate-in people who have heart failure and an implanted defibrillator. We want to find out if carvedilol is more effective than metoprolol succinate at preventing dangerous heart rhythm problems, hospitalizations for heart issues, and deaths caused by heart disease.

Comparative Effectiveness of Prophylactic ICD versus Non-ICD Therapy in Contemporary Heart Failure Patients with a Low Risk for Arrhythmic Death (CONTEMP-ICD)

Posted on by Jodi Snare

Page last updated May 11, 2026

ClinicalTrials.gov#: NCT06543446
Study Design: Intervention Trial
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement
Principal Investigator: Ilan Goldenberg
Institution: University of Rochester
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2024
Study Duration: 2024 – 2026
Participating PCORnet® Clinical Research Networks: GPC, PaTH
Therapeutic Area: Cardiovascular
Status: Terminated

Research Question(s):
Is implantable cardioverter-defibrillator beneficial in eligible heart failure patients with low arrhythmia risk?

Primary Publication(s):

Goldenberg I, Zareba W, Ezekowitz JA, et al. Rationale and design of the comparative effectiveness of ICD vs non-ICD therapy in contemporary heart failure patients at a low risk for arrhythmic death (CONTEMP-ICD) trial. Am Heart J. 2026;291:162-174. doi:10.1016/j.ahj.2025.08.020

Goldenberg I, Ezekowitz J, Albert C, et al. Reassessing the need for primary prevention implantable cardioverter defibrillators in contemporary patients with heart failure. Heart Rhythm. 2025;22(4):1040-1051. doi:10.1016/j.hrthm.2024.10.078