Studies

Oregon Medicaid Policy, Social Services, and Health (RESOLVE)

Posted on by Jodi Snare

Page last updated June 06, 2026

Study Design: Other
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement
Principal Investigator: Caroline Fichtenberg and Danielle Hessler Jones
Institution: University of California, San Francisco
PCORnet® Network Partner: REACHnet
Funder: Federal (NIH)
Funding Date: 2024
Study Duration: 2024 – 2029
Participating PCORnet® Clinical Research Networks: ADVANCE, REACHnet
Therapeutic Area: Healthcare Delivery, Cardiovascular, Endocrinology, Healthcare Delivery, Health Disparities, Mental and Behavioral Health, Other
Status: Active, not recruiting

Research Question(s):

Oregon implemented new Medicaid policies intended to increase referrals to connect patients endorsing specific social risks with local non-medical services.

  1. How do Oregon's new Medicaid policies impact rates of screening, referrals, and receipt of services for
    social needs?
  2. Do these policies decrease the difference in rates of screening, referrals, and receipt of services between various demographic groups?
  3. How do screening, referrals, and receipt of services for social needs impact chronic disease outcome and
    healthcare utilization? Is the impact different for various demographic groups?

AR² – Autism Replication, Validation, and Reproducibility Center

Posted on by Jodi Snare

Page last updated May 11, 2026

Study Design: Retrospective Observational Trial
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement
Principal Investigator: Judy Zhong
Institution: Weill Cornell Medicine
PCORnet® Network Partner: INSIGHT
Funder: Federal (NIH)
Funding Date: 2025
Study Duration: 2025 – 2028
Participating PCORnet® Clinical Research Networks: ADVANCE, GPC, INSIGHT, PEDSnet, STAR
Therapeutic Area: Intellectual and Developmental Disabilities (IDDs); Data Science
Status: Active, not recruiting

Research Question(s):

The study focuses on making autism research more reliable and widely applicable. We are creating the Autism Replication, Validation, and Reproducibility (AR²) Center to ensure that findings from autism data science projects can be independently verified and reproduced by providing complete, transparent packages, including data, code, and documentation.

By using diverse datasets from across the U.S., we aim to confirm that research results hold true for different populations and settings. This effort will promote best practices, share resources openly, and help translate autism research into real-world clinical care and policy.

Comparing Two Durations of Antibiotic Treatment for Children Hospitalized with Common Infections

Posted on by Jodi Snare

Page last updated March 12, 2026

Study Design: Intervention Trial
PCORnet Infrastructure: Single IRB, Patient partners or engagement
Principal Investigator: Sunitha Kaiser and Katherine Auger
Institution: University of California, San Francisco
PCORnet® Network Partner: REACHnet
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2025
Study Duration: 2025 – 2032
Participating PCORnet® Clinical Research Networks: GPC, OneFlorida+, PaTH, PEDSnet, REACHnet, STAR
Therapeutic Area: Infectious Disease
Status: Enrolling by invitation

Research Question(s):
For children hospitalized with pneumonia, skin infections, or urinary infections, do they recover better and have fewer side effects with a 5-day course of antibiotics, or a 10-day course of antibiotics?

A Randomized Controlled Trial Comparing Renal Effects of Vancomycin Combined With Either Piperacillin/tazobactam or Meropenem

Posted on by Jodi Snare

Page last updated February 4, 2026

Study Design: Intervention Trial
PCORnet Infrastructure: Single IRB, Patient partners or engagement, Clinical Research Collaboration Agreement
Principal Investigator: Daniel Freilich
Institution: Other
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2025
Study Duration: 2026 – 2029
Participating PCORnet® Clinical Research Networks: ADVANCE, GPC, INSIGHT, OneFlorida+, PaTH, REACHnet, STAR
Therapeutic Area: Infectious Disease; Nephrology
Status: Not yet recruiting

Research Question(s): 1) In hospitalized patients with severe infections, does the antibiotic combination workhorse, vancomycin and piperacillin/tazobactam (VPT), cause more kidney injury than another standard antibiotic combination, vancomycin and meropenem (VM), and 2) what is VPT's relative impact on other patient centric outcomes such as mortality, other kidney effects, hospital length of stay, readmissions, complications, and quality of life.

The Dose Trial: Dose Intensity of Behavioral Interventions for Childhood Obesity

Posted on by Jodi Snare

Page last updated July 9, 2026

ClinicalTrials.gov#: NCT06654323
Study Design: Intervention Trial
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement, Clinical Research Collaboration Agreement
Principal Investigator: Bill Heerman
Institution: Vanderbilt University Medical Center
PCORnet® Network Partner: STAR
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2024
Study Duration: 2024 – 2030
Participating PCORnet® Clinical Research Networks: REACHnet, STAR
Therapeutic Area: Metabolic Disorders; Other, Pediatric Obesity
Status: Recruiting

Research Question(s):

Can children with obesity achieve meaningful improvements in their health with fewer hours of treatment than currently recommended? This study is testing whether shorter versions of a family-based lifestyle program, delivered through pediatric clinics, are just as effective as the full 26-hour version currently recommended by national guidelines. The goal is to find out if families can benefit from a lower-dose program that is easier to complete, while still helping children improve their weight, quality of life, and health behaviors.

Clinical Outcomes of Medications Post Anti-TNF: Researching Effectiveness in Pediatric IBD

Posted on by Jodi Snare

Page last updated July 09, 2026

Study Design: Prospective Observational Study
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement, Clinical Research Collaboration Agreement
Principal Investigator: Michael D. Kappelman
Institution: University of North Carolina at Chapel Hill
PCORnet® Network Partner: STAR
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2025
Study Duration: 2025 – 2031
Participating PCORnet® Clinical Research Networks: GPC, INSIGHT, OneFlorida+, PEDSnet, PaTH, REACHnet, STAR
Therapeutic Area: Gastroenterology
Status: Recruiting

Research Question(s):

  1. Can we determine which medicine is the safest and most effective at treating kids with Crohn's disease or ulcerative colitis when the first medicine they take does not work for them?

Advancing Public Health Use of Electronic Health Record Data

Posted on by Jodi Snare

Page last updated May 11, 2026

Study Design: Other, Data Science
PCORnet Infrastructure: Common Data Model (CDM), Patient partners or engagement
Principal Investigators: Jason P. Block and Tom Carton
Institution: Other
Funder: Federal (CDC)
Funding Date: 2024
Study Duration: 2024 – 2026
Participating PCORnet® Clinical Research Networks: ADVANCE, GPC, INSIGHT, OneFlorida+, PaTH, PEDSnet, REACHnet, STAR
Therapeutic Area: Infectious Disease
Condition: Other; Public health surveillance across COVID-19, influenza and select chronic diseases and other infectious diseases
Status: Active, not recruiting

Research Question(s):

How can we use nationally distributed healthcare data infrastructure to (1) improve the capacity of data and information systems to conduct monitoring and surveillance and (2) increase the capability to use data to inform public health decision-making and support evidence-based practices and policies?

Primary Publication(s):

Zhang, Y., Romieu-Hernandez, A., Boehmer, T.K. et al. Association between SARS-CoV-2 infection and select symptoms and conditions 31 to 150 days after testing among children and adults. BMC Infect Dis 24, 181 (2024). doi.org/10.1186/s12879-024-09076-8

Jackson SL, Lekiachvili A, Block JP, et al. Preventive Service Usage and New Chronic Disease Diagnoses: Using PCORnet Data to Identify Emerging Trends, United States, 2018-2022. Prev Chronic Dis. 2024 Jul 3;21:E49. doi: 10.5888/pcd21.230415

Ghildayal N, Nagavedu K, Wiltz JL, et al. Public Health Surveillance in Electronic Health Records: Lessons From PCORnet. Prev Chronic Dis. 2024 Jul 11;21:E51. doi: 10.5888/pcd21.230417

Improving Outcomes and Reducing Disparities for Patients With Inflammatory Bowel Disease Through Epidemiology and Enhanced Disease Management (PROMOTE IBD)

Posted on by Jodi Snare

Page last updated August 04, 2026

ClinicalTrials.gov#: NCT06424769
Study Design: Intervention Trial
PCORnet Infrastructure: Single IRB, Patient partners or engagement
Principal Investigator: Michael D. Kappelman
Institution: University of North Carolina at Chapel Hill
PCORnet® Network Partner: STAR
Funder: Federal (CDC)
Funding Date: 2023
Study Duration: 2023 – 2028
Participating PCORnet® Clinical Research Networks: INSIGHT, PaTH, REACHnet, STAR
Therapeutic Area: Gastroenterology
Status: Enrolling by Invitation

Research Question(s):

  1. Does access to new, text messaging-based communications tools help teenagers and adults with IBD (Crohn's Disease and Ulcerative Colitis) feel better able to manage their condition?

A Comparative Effectiveness Study of Oral Medications Used for Migraine Prevention: The SPT Comparison Study

Posted on by Jodi Snare

Page last updated October 29, 2025

Study Design: Intervention Trial
PCORnet Infrastructure: Single IRB, Patient partners or engagement
Principal Investigator: Todd Schwedt
Institution: Mayo Clinic
PCORnet® Network Partner: STAR
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2024
Study Duration: 2025 – 2029
Participating PCORnet® Clinical Research Networks: GPC, One Florida+, PaTH, STAR
Therapeutic Area: Neurology
Status: Recruiting

Research Question(s):

Is a newer oral migraine preventive medication (atogepant) more effective for treating migraines than two older medications (propranolol, topiramate), each of which is commonly used in clinical practice and has strong levels of evidence supporting their efficacy?

Equity in Treatment for Asthma Between Latinos and Whites

Posted on by Jodi Snare

Page last updated May 11, 2026

Study Design: Retrospective Observational Study
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement
Principal Investigator: John Heintzman
Institution: OCHIN
PCORnet® Network Partner: ADVANCE
Funder: Federal (NIH/NHLBI)
Funding Date: 2025
Study Duration: 2025 – 2028
Participating PCORnet® Clinical Research Networks: ADVANCE, REACHnet
Therapeutic Area: Pulmonology
Status: Active, not recruiting

Research Question(s):

  1. How does the quality of asthma care - including timely diagnosis, assessment, immunization, medication prescription, and access to testing - vary when comparing Latino adults to non-Latino white adults?
  2. Among adults with asthma, how do Latino adults vary from non-Latino white adults in how they utilize primary asthma care in Community Health Centers?
  3. How do Latino and non-Latino white adults with asthma vary in how they utilize acute care, including clinic visits, emergency department visits, and inpatient hospitalization?
  4. Do different subgroups of Latino-Americans, such as Latinos of Mexican, Dominican, or Cuban heritage, utilize asthma care at different rates and receive care of differing quality?
  5. Relatively, do individual factors (e.g., income, preferred language, insurance coverage, and migrant status) or community-level factors (e.g., community poverty, education, and environmental factors) contribute more to a person's (focusing on Latinos, but including others as well) likelihood of receiving primary asthma care, utilizing acute care, or experiencing asthma-related death?