Studies

Improving Outcomes and Reducing Disparities for Patients With Inflammatory Bowel Disease Through Epidemiology and Enhanced Disease Management (PROMOTE IBD)

Posted on by Jodi Snare

Page last updated August 21, 2025

ClinicalTrials.gov#: NCT06424769
Study Design: Intervention Trial
PCORnet Infrastructure: Single IRB, Patient partners or engagement
Principal Investigator: Michael D. Kappelman
Institution: University of North Carolina at Chapel Hill
PCORnet® Network Partner: STAR
Funder: CDC
Funding Date: 2023
Study Duration: 2023 – 2028
Participating PCORnet® Clinical Research Networks: INSIGHT, PaTH, REACHnet, STAR
Therapeutic Area: Gastroenterology
Status: Recruiting

Research Question(s):

  1. Does access to new, text messaging-based communications tools help teenagers and adults with IBD (Crohn's Disease and Ulcerative Colitis) feel better able to manage their condition?

A Comparative Effectiveness Study of Oral Medications Used for Migraine Prevention: The SPT Comparison Study

Posted on by Jodi Snare

Page last updated October 29, 2025

Study Design: Intervention Trial
PCORnet Infrastructure: Single IRB, Patient partners or engagement
Principal Investigator: Todd Schwedt
Institution: Mayo Clinic
PCORnet® Network Partner: STAR
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2024
Study Duration: 2025 – 2029
Participating PCORnet® Clinical Research Networks: GPC, One Florida+, PaTH, STAR
Therapeutic Area: Neurology
Status: Recruiting

Research Question(s):

Is a newer oral migraine preventive medication (atogepant) more effective for treating migraines than two older medications (propranolol, topiramate), each of which is commonly used in clinical practice and has strong levels of evidence supporting their efficacy?

Equity in Treatment for Asthma Between Latinos and Whites

Posted on by Jodi Snare

Page last updated December 1, 2025

Study Design: Retrospective Observational Study
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement
Principal Investigator: John Heintzman
Institution: OCHIN
PCORnet® Network Partner: ADVANCE
Funder: NIH/NHLBI
Funding Date: 2025
Study Duration: 2025 – 2028
Participating PCORnet® Clinical Research Networks: ADVANCE, REACHnet
Therapeutic Area: Pulmonology
Status: Active, not recruiting

Research Question(s):

  1. How does the quality of asthma care - including timely diagnosis, assessment, immunization, medication prescription, and access to testing - vary when comparing Latino adults to non-Latino white adults?
  2. Among adults with asthma, how do Latino adults vary from non-Latino white adults in how they utilize primary asthma care in Community Health Centers?
  3. How do Latino and non-Latino white adults with asthma vary in how they utilize acute care, including clinic visits, emergency department visits, and inpatient hospitalization?
  4. Do different subgroups of Latino-Americans, such as Latinos of Mexican, Dominican, or Cuban heritage, utilize asthma care at different rates and receive care of differing quality?
  5. Relatively, do individual factors (e.g., income, preferred language, insurance coverage, and migrant status) or community-level factors (e.g., community poverty, education, and environmental factors) contribute more to a person's (focusing on Latinos, but including others as well) likelihood of receiving primary asthma care, utilizing acute care, or experiencing asthma-related death?

Tube Size Randomized Trial during Emergency Tracheal Intubation

Posted on by Jodi Snare

Page last updated November 07, 2025

Study Design: Intervention Trial
PCORnet Infrastructure: Single IRB, Patient partners or engagement, Clinical Research
Collaboration Agreement
Principal Investigator: Jonathan Casey
Institution: Vanderbilt University Medical Center
PCORnet® Network Partner: STAR
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2024
Study Duration: 2025 – 2029
Participating PCORnet® Clinical Research Networks: ADVANCE, OneFlorida+, STAR
Therapeutic Area: Pulmonology
Status: Enrolling by invitation

Research Question(s):

  1. Do smaller breathing tubes prevent long-term problems with breathing, speaking and swallowing?
  2. Are smaller breathing tubes as good as larger breathing tubes for getting patients through their illness and off the breathing machine?

Comparative Effectiveness of Carvedilol versus Metoprolol Succinate in Heart Failure Patients with an Implantable Cardioverter Defibrillator

Posted on by Jodi Snare

Page last updated August 22, 2025

ClinicalTrials.gov#: NCT06964464
Study Design: Intervention Trial
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement
Principal Investigator: Mehmet Aktas
Institution: University of Rochester
PCORnet® Network Partner: External
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2024
Study Duration: 2025 – 2031
Participating PCORnet® Clinical Research Networks: GPC, INSIGHT, PaTH, REACHnet
Therapeutic Area: Cardiovascular
Status: Recruiting

Research Question(s):
In this study, we are comparing two commonly used beta-blockers-carvedilol and metoprolol succinate-in people who have heart failure and an implanted defibrillator. We want to find out if carvedilol is more effective than metoprolol succinate at preventing dangerous heart rhythm problems, hospitalizations for heart issues, and deaths caused by heart disease.

Comparative Effectiveness of Prophylactic ICD versus Non-ICD Therapy in Contemporary Heart Failure Patients with a Low Risk for Arrhythmic Death (CONTEMP-ICD)

Posted on by Jodi Snare

Page last updated April 14, 2026

Study Website: https://contemp-icd-study.org/
ClinicalTrials.gov#: NCT06543446
Study Design: Intervention Trial
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement
Principal Investigator: Ilan Goldenberg
Institution: University of Rochester
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2024
Study Duration: 2024 – 2031
Participating PCORnet® Clinical Research Networks: GPC, PaTH
Therapeutic Area: Cardiovascular
Status: Terminated

Research Question(s):
Is implantable cardioverter-defibrillator beneficial in eligible heart failure patients with low arrhythmia risk?

Primary Publication(s):

Goldenberg I, Zareba W, Ezekowitz JA, et al. Rationale and design of the comparative effectiveness of ICD vs non-ICD therapy in contemporary heart failure patients at a low risk for arrhythmic death (CONTEMP-ICD) trial. Am Heart J. 2026;291:162-174. doi:10.1016/j.ahj.2025.08.020

Goldenberg I, Ezekowitz J, Albert C, et al. Reassessing the need for primary prevention implantable cardioverter defibrillators in contemporary patients with heart failure. Heart Rhythm. 2025;22(4):1040-1051. doi:10.1016/j.hrthm.2024.10.078

Implementation Program to Improve Screening and management for CKD in Diabetes (IRIS-CKD)

Posted on by Jodi Snare

Page last updated December 8, 2025

ClinicalTrials.gov#: NCT06906627 - Program 1
ClinicalTrials.gov#: NCT06906640 - Program 2
Study Design: Prospective Observational Study
PCORnet Infrastructure: Patient partners or engagement
Principal Investigator: Neha Pagidipati
Institution: Duke Clinical Research Institute
PCORnet® Network Partner: The Coordinating Center for PCORnet®
Funder: Bayer, Boehringer Ingelheim, Lilly
Funding Date: 2024
Study Duration: 2024 – 2026
Participating PCORnet® Clinical Research Networks: INSIGHT, OneFlorida+, PaTH, REACHnet, STAR 
Therapeutic Area: Nephrology
Condition: CKD in Diabetes
Status: Recruiting

Research Question(s):
IRIS-CKD is a project focused on improving how doctors check for and treat chronic kidney disease (CKD) in people with type 2 diabetes (T2D). The main goals of the project are to:

  • Increase the number of people with type 2 diabetes who get screened for chronic kidney disease.
  • Ensure that more patients with both chronic kidney disease and type 2 diabetes receive the treatments recommended by medical guidelines.

Achieving Equity: Inclusion of Adults with Congenital Heart Disease (CHD) Living with Neurodevelopmental Disorders (NDDs) in Patient Centered Outcomes Research

Posted on by Jodi Snare

Page last updated April 14, 2026

Study Design: Other, Mixed method study - has a prospective cohort
PCORnet Infrastructure: Common Data Model (CDM), Patient partners or engagement
Principal Investigator: Anitha John
Institution: Children's National Hospital
PCORnet® Network Partner: PEDSnet
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2024
Study Duration: 2024 – 2028
Participating PCORnet® Clinical Research Networks: OneFlorida+; PEDSnet, REACHnet, STAR
Therapeutic Area: Cardiovascular
Status: Recruiting

Research Question(s):

1) What are the engagement strategies needed for individuals living with NDD and CHD?
2) What metrics (such as surveys, focus groups, etc.) can be employed to measure engagement in individuals living with NDD?

USDHub: Community Resource for Urinary Stone Disease Research

Posted on by Jodi Snare

Page last updated August 22, 2025

Study Design: Other, Real World Evidence
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement
Principal Investigator: Ryan Hsi
Institution: Vanderbilt University Medical Center
PCORnet® Network Partner: STAR
Funder: NIH
Funding Date: 2024
Study Duration: 2024 – 2029
Participating PCORnet® Clinical Research Networks: PEDSnet, STAR
Therapeutic Area: Nephrology
Status: Active, not recruiting

Research Question(s): Can a data resource be created to strengthen urinary stone disease research that will generate new knowledge that improves the health of all individuals with urinary stone disease?

A Clinical Trial Readiness Study of Patient Reported Outcome Measures in TTP (THINK-TTP)

Posted on by Jodi Snare

Page last updated April 14, 2026

Study Design: Prospective Observational Study
PCORnet Infrastructure: Single IRB, Patient partners or engagement
Principal Investigator: Toyosi Onwuemene and Theresa Coles
Institution: Duke University
PCORnet® Network Partner: STAR
Funder: Federal (NIH/NCATS)
Funding Date: 2024
Study Duration: 2024 – 2026
Participating PCORnet® Clinical Research Networks: GPC, STAR
Therapeutic Area: Rare Diseases
Status: Active, not recruiting

Research Question(s): Can we develop a consensus-based strategy that comprehensively measures TTP-associated cognitive function impacts from the patient perspective?