Study Updated 03/05/2024
Study Website: The BACK-OFF JSpA Study
ClinicalTrials.gov#: NCT04891640
Study Design: Interventional
PCORnet Infrastructure: Collaboration, CDM (+supplemental data), Engagement, Single IRB
Principal Investigator: Pamela Weiss
Site Name: The Children’s Hospital of Philadelphia
PCORnet® Network Partner: PEDSnet
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2020
Study Duration: 2021 – 2025
Participating Clinical Research Networks: GPC, PaTH, PEDSnet, STAR
Therapeutic Area: Auto Immune
Condition: Juvenile Spondyloarthritis
Population: 8 Years to 21 Years (Child, Adult)
Status: Recruiting
Research Question(s):
This trial will compare how patients with inactive spondyloarthritis on tumor necrosis factor inhibitor (TNFi) treatment respond to three treatment options that doctors currently use:
- Continue standard TNFi medication,
- Space out the time between usual TNFi medication doses, or
- Stop the TNFi medication. If we can safely prolong the time between doses or completely take away TNFi therapy in this population, we may remove unnecessary medication exposure, improve patient quality of life, and lower medication costs.