Featured In This Issue
- New Year, New Ways to Connect with Us: Follow PCORnet on LinkedIn!
- New Pathways for Patient-Centered Research: PCORI® Approves $134M to Expand Infrastructure for PCORnet® Studies
- Available Now! Two New Data Reports on Mental and Behavioral Health and the Pediatric Population Provide Research Opportunities using PCORnet
- New PCORnet® Study on Pediatric Inflammatory Bowel Disease
- PCORnet® Study Shows Digital Interventions May Help Reduce Early Childhood Obesity
Funding Opportunities: Share the Latest Funding Announcements with Your Network of Researchers
Upcoming & Recent Events: Explore Learning Opportunities and Strengthen Your Research
Research Results: The Latest Published Insights from Studies Powered by PCORnet®
A National Health & Research Data Resource for Patient-Centered Comparative Clinical Effectiveness Research
Connect with us
Subscribe to receive the newsletter via email.
Complete the PCORnet® Front Door form to get in touch!
New Year, New Ways to Connect with Us: Follow PCORnet on LinkedIn!
We’re excited to announce that PCORnet is now on LinkedIn! Follow us to join the conversation, stay connected, and get the latest updates on how the PCORnet infrastructure is improving the nation’s capacity to efficiently conduct patient-centered comparative clinical effectiveness research (CER) through health data, research expertise, and patient insights.
New Pathways for Patient-Centered Research: PCORI Approves $134M to Expand Infrastructure for PCORnet® Studies
With the new year comes an exciting new commitment to national-scale patient-centered research. We are thrilled to share that PCORI is investing $134 million over the next four years to strengthen the PCORnet infrastructure, expanding its capacity to power large-scale patient-centered CER and other health research. This investment will support initiatives to enhance awareness of PCORnet, bolster patient engagement, and optimize sharing of study results.
Available Now! Two New Data Reports on Mental and Behavioral Health and the Pediatric Population Provide Research Opportunities using PCORnet
Interested in conducting national-scale research on mental and behavioral health or pediatric populations? PCORnet may be used by all interested investigators, regardless of affiliation or source of funding. These two new data reports are designed to provide researchers and the public with insights into research opportunities using the network:
Data reports are also available for other areas of research, including maternal morbidity and mortality, telehealth, and intellectual and developmental disabilities. Most offer the largest national query of real-world data on conditions, populations, or service utilization.
New PCORnet® Study on Pediatric Inflammatory Bowel Disease Study 
PCORI will fund $14.4 million for a study leveraging the PCORnet infrastructure to explore new treatment options for pediatric inflammatory bowel diseases (PIBD). The study, “Comparative Effectiveness of Emerging Medications in Children with Inflammatory Bowel Disease,” led by Michael D. Kappelman, MD, MPH, professor of pediatrics and epidemiology at the UNC School of Medicine, will include 30 sites participating in PCORnet to compare the clinical effectiveness and safety of off-label medications in patients with PIBD for whom standard treatments are ineffective.
The study has the potential to transform care for the over 100,000 children in the U.S. living with PIBD, helping clinicians and families make more informed, evidence-based treatment decisions for patients who have not responded to first-line therapies. By filling a critical knowledge gap, the findings will guide treatment decisions, reduce uncertainty, and ultimately improve outcomes for PIBD patients who currently face limited options and significant treatment challenges.
“This will be a really exciting project with high impact,” said Kappelman, who is the principal investigator. “By systematically studying how we care for children with PIBD today, we will determine how best to care for these patients in the future.”
PCORnet® Study Shows Digital Interventions May Help Reduce Early Childhood Obesity
Results from Greenlight Plus, a PCORnet® Study, were recently published in JAMA, demonstrating that a health literacy–informed digital intervention improved child weight-for-length trajectory across the first 24 months of life and reduced childhood obesity at 24 months. Conducted across two PCORnet® Clinical Research Networks, INSIGHT and STAR, this PCORI-funded study involved families from diverse racial and ethnic backgrounds. The findings suggest a combined digital and clinical approach can play a role in promoting healthy growth patterns in early childhood, especially for those at higher risk of obesity due to socioeconomic or ethnic factors.
Please share new funding announcements with your network of researchers:
- PCORI is offering a Category 3 Broad Pragmatic Studies (BPS) funding opportunity for researchers interested in using the PCORnet infrastructure for patient-centered CER. This funding opportunity supports PCORnet® Studies with direct costs up to $12 million. PCORnet® Studies use the network to conduct observational studies and/or pragmatic trials that are national in scale. Category 3 PCORnet® Studies must include two or more PCORnet® CRNs and share study progress, performance metrics, and best practices to promote continuous learning and improvement.
- Letter of Intent (LOI) Deadlines
- Cycle 2: April 1, 2025
- Cycle 3: September 2025
- Letter of Intent (LOI) Deadlines
- The National Cancer Institute (NCI) will support multi-level intervention studies that address individual- and system-level barriers to transition from pediatric to adult care for survivors of childhood and adolescent cancers.
- Application Due Date: October 17, 2025
Explore these learning opportunities to strengthen your research and get inspired by other studies leveraging the PCORnet infrastructure.
Upcoming Best Practice Sharing Session Featuring ACTIV-6, a PCORnet® Study
Operational Overview and Lessons Learned from the ACTIV-6 Clinical Trial
- Join this session for highlights on some of the non-traditional approaches that were employed in this decentralized platform trial that used the PCORnet infrastructure to explore repurposed medications for the treatment of acute COVID-19.
- When: February 27 at 2:00 p.m. ET
- Contact [email protected] for a calendar invite
In Case You Missed It: Showcasing the PCORnet Infrastructure at the 2024 PCORI Annual Meeting
Researchers Share How the PCORnet Infrastructure Can Be Used to Address Maternal Health Disparities
- At the 2024 PCORI Annual Meeting, researchers showcased how they are using the PCORnet infrastructure to address U.S. maternal health disparities through the panel titled “Maternal Data Matters: Lessons from PCORnet®.”
The Latest Published Insights from Studies Powered by PCORnet®
Check out the most recent publications from study teams using the PCORnet infrastructure.
- Implementing Cancer Registry Data With the PCORnet Common Data Model: The Greater Plains Collaborative Experience (Funders: PCORI, the National Cancer Institute, and the National Institutes of Health)
- Major adverse cardiovascular events’ reduction and their association with glucose-lowering medications and glycemic control among patients with type 2 diabetes: A retrospective cohort study using electronic health records (Funders: National Center for Advancing Translational Sciences, National Institutes of Health, and PCORI)
- Risk of New-Onset Diabetes Before and During the COVID-19 Pandemic: A Real-World Cohort Study (Funders: National Institute for Diabetes and Digestive and Kidney Diseases of the National Institutes of Health and the Georgia Center for Diabetes Translation Research)
Want to know how the PCORnet infrastructure can support your work? Contact us at the PCORnet® Front Door, the access point for all PCORnet resources.
PCORnet® is intended to improve the nation’s capacity to efficiently conduct patient-centered health research, particularly comparative clinical effectiveness research (CER), by providing a large, highly representative network of health data, research expertise, and patient insights. PCORnet® has been developed with funding from the Patient-Centered Outcomes Research Institute (PCORI®).