A new PCORnet® Population Insights Report offers a national-scale look at more than 2 million patients with menopausal conditions and their healthcare experiences. The report draws on de-identified data from patients who received healthcare services at sites participating in PCORnet in 2024 and who received a menopausal condition diagnosis between 2020-2024.
The menopausal transition can be associated with a variety of symptoms, including hot flashes, bone loss, joint pain, depression, anxiety, and insomnia. These symptoms may have an even more pronounced health impact among women who experience early or premature menopause.
Across the network, the data include more than 1.4 million patients with symptoms associated with menopause, and over 30,000 experiencing premature menopause. The scale of these data highlights the potential of the PCORnet infrastructure to support observational studies and pragmatic trials that can help answer important questions about menopause and healthcare.
The report provides insights into the incidence of diagnoses of menopausal-related conditions within this specific population. While the overall prevalence of these conditions is likely higher, these data reflect patients that received care for menopausal conditions during this 5-year period.
| Menopausal Conditions | Patients | Percent |
| Asymptomatic Menopause | 1,486,534 | 54.8% |
| Menopausal and Other Perimenopausal Disorders | 1,467,175 | 54.1% |
| Excessive Premenopausal Bleeding | 71,232 | 2.6% |
| Post-procedure Ovarian Failure | 31,723 | 1.2% |
| Premature Menopause | 30,557 | 1.1% |
The report provides insights into the demographic and geographic characteristics of this patient population, as well as care settings, co-occurring chronic conditions, potential menopausal symptoms, prescribed medications and related procedures. Among patients with menopausal conditions:
- The most common potential menopausal symptoms were fatigue (29.5%), headaches/migraines (23.4%), and palpitations (12.5%).
- 4% received a bone mineral density test.
- The most commonly prescribed medications included antihypertensives (33.6%), hormonal therapies (18.5%), selective serotonin reuptake inhibitors (12.3%) and GLP-1 receptor agonists (7.8%).
- Medications for hot flashes were prescribed to 0.3% of patients.
- 8% used telehealth.
With data from more than 28 million female patients across the network, the PCORnet infrastructure can support research addressing a wide range of women’s health questions. In addition to menopausal conditions, the network also includes information relevant to research on breast cancer, uterine cancer, endometriosis and other health conditions.
The report is part of a growing collection of PCORnet Population Insights Reports, some of which offer the largest national query of real-world data on specific health conditions, populations, or use of healthcare services. Together, these reports demonstrate how PCORnet-accessible data can support patient-centered health research planning and help advance evidence that is relevant and usable for patients, caregivers, and the broader healthcare community.
Reports on several healthcare topics, along with highlights and illustrations, are available on the Population Insights page.
Contact the PCORnet® Front Door to learn how you can use PCORnet resources to support your patient-centered health research.