Featured In This Issue
- PCORnet® Playbook
- New PCORnet® Studies
- New PCORnet® Population Insights Reports
Funding Opportunities: Share the Latest Funding Announcements with Your Network of Researchers
Upcoming Events: Explore Learning Opportunities and Strengthen Your Research
- Upcoming Best Practice Sharing Session
- September 8, from 1-2 pm (ET) | Tips and Tricks for Starting up PCORnet® Studies.
- PCORnet Roadshow Virtual Events
- September 11, from 8 am - 4 pm (ET) in Pittsburgh, PA
- September 26, from 8 am - 4 pm (PT) in Portland, OR
- 2025 PCORI Annual Meeting
- October 21 - 22 in Washington, D.C.
Research Results: Read the Latest Published Insights from Studies Powered by PCORnet®
A National Health & Research Data Resource for Patient-Centered Comparative Clinical Effectiveness Research
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PCORnet® Playbook
Your Guide to Navigating PCORnet
The PCORnet® Playbook is your go-to guide for using PCORnet, whether you're a researcher, patient or community partner, clinician, caregiver, or part of a research team. Thoughtfully organized into clear, easy-to-navigate sections, the PCORnet® Playbook is designed to help you navigate PCORnet resources and services. The Playbook helps research teams make the best use of and demystify the many PCORnet research tools to support the design and conduct of meaningful, patient-centered studies.
The PCORnet® Playbook provides insights such as:
- Understanding the national scope and scale of PCORnet resources for patient-centered health research.
- Designing high-quality, large-scale research projects using PCORnet services, including support for engagement, data, and outreach.
- What to expect when collaborating with PCORnet® Network Partners.
Watch this brief video to explore the PCORnet® Playbook’s features and learn how to get started.
PCORnet® Study Spotlight
Two new PCORnet® Studies are harnessing the power of PCORnet to conduct patient-centered comparative clinical effectiveness research in emergency tracheal intubation and pediatric inflammatory bowel disease (PIBD). Both studies aim to address critical gaps in areas of clinical care that have been difficult to study.
BREATHE (Rationale and Design of the Tube Size Randomized Trial during Emergency Tracheal Intubation), is the first PCORnet® Study looking at the intubation process in emergency and critical care settings. The study will run from April 2025 to 2029, with the goal of recruiting more than 3,100 patients. To date, BREATHE includes four participating sites.
The second PCORnet® Study, COMPARE (Comparative Effectiveness of Emerging Medications in Children with Inflammatory Bowel Disease), is investigating the real-world effectiveness of commonly prescribed new treatments for children with PIBD. To date, COMPARE has 28 participating sites. The study will run from April 2024 to 2031, with the goal of recruiting 1,100 patients.
Learn more about these two new PCORnet® Studies and how the PCORnet infrastructure is uniquely equipped to support these studies.
New PCORnet® Population Insights Reports
Women's Health
A new report on more than 35 million women who received health care services at 71 clinical sites across PCORnet is now available. This report is a crucial resource for researchers, enabling them to assess how PCORnet data resources can be used to conduct national-scale, patient-centered comparative clinical effectiveness research to improve women’s health.
Gene Therapy
PCORnet has released a new Gene Therapy report offering key insights into patients receiving gene therapies within healthcare settings across PCORnet. This report is a timely resource for researchers and the public alike, illustrating how the PCORnet infrastructure enables large-scale studies on the real-world use of gene therapies and how the PCORnet infrastructure is helping advance gene therapy research across the country.
New: PCORI Broad Pragmatic Studies (BPS) Category 3 Funding Opportunity
On August 12, PCORI released a Category 3 BPS funding opportunity for researchers aiming to use PCORnet to conduct patient-centered comparative clinical effectiveness research (CER).
PCORnet® Studies under this category use the network to conduct observational studies and pragmatic trials that are national in scale. Category 3 PCORnet® Studies must include two or more PCORnet® Clinical Research Networks and share study progress, performance metrics, and best practices to foster continuous learning and improvement.
- Letter of Intent (LOI) deadline: September 23, 2025
- Learn more
Additional PCORI funding opportunities also opened for LOI submissions on August 12. We encourage you to review all PCORI funding opportunities and consider how you can use PCORnet resources to achieve your research goals.
- Addressing Rare Diseases
- Advancing the Science of Engagement in Research
- Improving Methods for Patient-Centered CER
- Phased Large Awards for Comparative Effectiveness Research (PLACER)
Engagement Awards: Fall Cycle
On July 17, PCORI released the Fall 2025 Cycle of PCORI Funding Announcements (PFAs) for the Eugene Washington PCORI Engagement Award Program. Three award types are available: Capacity Building, Convening Support, and Dissemination Initiative.
The Engagement Award Program does not fund research studies, but rather supports projects that encourage active, meaningful involvement of patients, caregivers, and the broader healthcare community as integral members of the CER enterprise.
Letters of Intent are due by September 29, 2025.
Explore these learning opportunities to strengthen your research and gain insights from studies utilizing the PCORnet infrastructure.
Discover where PCORnet® Network Partners are presenting and how you can learn more about their innovative approach to patient-centered research.
Best Practice Sharing Session
Join the Coorinating Center for PCORnet® for a Best Practice Sharing Session webinar. Contact [email protected] for a calendar invite.
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- September 8, from 1-2 pm (ET)
Tips and Tricks for Starting Up PCORnet® Studies. In this webinar, the speakers will present tips and tricks from the Trial Innovation Network and discuss efficiencies in contracts and study start-up activities. Essentia Health will join the second half of the session to review case examples from PCORnet® Studies PREVENTABLE, PRECIDENTD and V-INCLUSION.
- September 8, from 1-2 pm (ET)
PCORnet Roadshow: Register Now for Virtual Sessions Hosted by PCORnet® Clinical Research Networks
Take advantage of two new PCORI-funded opportunities to engage with PCORnet® Clinical Research Networks (CRNs). These events are ideal for researchers, providers, and patients who want to learn more about the research capabilities enabled by PCORnet. Please share these opportunities with your colleagues.
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- September 11, from 8 am - 4 pm (ET), the PaTH CRN is hosting a regional information session in Pittsburgh, PA. Register to attend virtually.
- September 26, from 8 am - 4 pm (PT), the ADVANCE CRN is hosting a regional information session in Portland, OR. Register to attend virtually.
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2025 PCORI Annual Meeting
The 2025 PCORI Annual Meeting will be held in Washington, D.C., on October 21-22. This two-day event will bring together patients, caregivers, and the broader healthcare community to network, learn about the latest findings from PCORI-funded research and research-related projects, and share in rich discussions aimed at advancing patient-centered health research.
For more information and registration details, please visit the 2025 PCORI Annual Meeting webpage.
The Latest Published Insights from Studies Powered by PCORnet®
Explore recently published findings from research teams leveraging the PCORnet infrastructure:
- Predicting Heart Failure Outcomes Using Patient-Reported Health Status: Real-World Validation of the KCCQ-12
(Funder: PCORI®) - Medicaid Eligibility Expansion Regardless of Immigration Status and Insurance Coverage Among Latinos Seen in Community Health Centers, 2018‒2023
(Funder: American Cancer Society and the Silver Family Innovation Fund) - Disparities in Initial Antihypertensive Intensity by Sex, Race and Ethnicity in Newly-Treated Patients with Hypertension
(Funder: NIH National Heart, Lung, and Blood Institute) - Federated learning with multi-cohort real-world data for predicting the progression from mild-cognitive impairment to Alzheimer's disease
(Funders: Ed and Ethel Moore Alzheimer's Disease Research Program of the Florida Department of Health and the OneFlorida+ PCORnet® Clinical Research Network, funded by PCORI®)
Follow PCORnet on LinkedIn
Did you know that PCORnet is now on LinkedIn? Follow us to join the conversation, stay connected, and get the latest updates on how the PCORnet infrastructure is improving the nation’s capacity to efficiently conduct patient-centered comparative clinical effectiveness research (CER) through health data, research expertise, and patient insights.
Interested in how the PCORnet infrastructure can support your research? Connect with the PCORnet® Front Door—your gateway to opportunities.
PCORnet® is intended to improve the nation’s capacity to efficiently conduct patient-centered health research, particularly comparative clinical effectiveness research (CER), by providing a large, highly representative network of health data, research expertise, and patient insights. PCORnet® has been developed with funding from the Patient-Centered Outcomes Research Institute (PCORI®).