On April 1, PCORI will release the Broad Pragmatic Studies (BPS) PCORI Funding Announcement (PFA) to support high-quality patient-centered comparative clinical effectiveness research (CER). Category 3 supports PCORnet® Studies with direct costs of up to $12 million.
PCORnet® Studies are defined as those that:
- Include two or more PCORnet® Clinical Research Networks (CRNs)
- Share study progress and performance metrics
- Exchange best practices with the network to promote continuous learning and improvement
- Leverage the PCORnet® Common Data Model as appropriate
PCORI has identified four specific areas of emphasis for this PFA: addressing obesity; diabetes prevention, care and treatment; management of urogynecological and pelvic pain; and pain management for individuals living with Sickle Cell Disease.
Letters of Intent (LOIs) are due April 28.
Ready to learn more and apply? Take these three steps to prepare:
- Contact the PCORnet® Front Door as soon as possible. All applicants submitting to the BPS Category 3 PFA are required to contact the PCORnet® Front Door prior to submitting their LOI. The PCORnet® Front Door can advise on study feasibility and costs associated with using PCORnet, provide data to inform study design, offer best practices for stakeholder engagement, and more.
- Register for the April 9 PCORI Applicant Town Hall to learn more about this PFA and how to submit a responsive LOI and application.
- Check out this webinar for an overview of PCORnet and the specific requirements for the Category 3: PCORnet® Studies option in the BPS PFA.
On April 1, PCORI will also release a PFA on Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research PCORI Funding Announcement.
This PFA seeks to fund studies that address high-impact methodological gaps in patient-centered CER and might lead to improvements in the strength and quality of evidence generated by CER studies. Applicants considering this PFA are encouraged to partner with PCORnet® Network Partners.
The preannouncement provides potential applicants additional time to identify collaborators, obtain patient and partner input and develop responsive, high-quality applications.
For the Cycle 2 2026 Methods PFA, PCORI has identified the following areas as program priorities:
- Methods To Support the Use of Patient-Centered Measurement in Patient-Centered CER
- Methods To Support the Use of Real-World Data (RWD) in Multi-Site Patient-Centered CER (formerly Methods to Support Data Research Networks)
- Methods To Improve the Use of Artificial Intelligence (AI) and Machine Learning (ML) in Patient-Centered CER
- Methods To Improve Study Design in Patient-Centered CER
To learn more about this funding opportunity, attend the PCORI Applicant Town Hall on April 6, noon – 1 pm (ET).
Additional PFAs opening April 1 (with LOIs due April 28) include:
- Addressing Sensory Health Needs Across the Lifespan
- Applicant Town Hall – April 7, noon – 1 pm (ET) (Learn more)
- Phased Large Awards for Comparative Effectiveness Research PCORI Funding Announcement
- Applicant Town Hall – April 8, 11:30 am – 12:30 pm (ET) (Learn more)
| Title | LOI Due Date | Applicant Town Hall Date |
|---|---|---|
| Broad Pragmatic Studies (BPS) PCORI Funding Announcement (PFA) | April 28 | April 9, 11:30 am – 1 pm (ET) Learn more |
| Improving Methods for Conducting Patient-Centered Comparative Clinical Effectiveness Research PCORI Funding Announcement | April 28 | April 6, noon – 1 pm (ET) Learn more |
| Addressing Sensory Health Needs Across the Lifespan | April 28 | April 7, noon – 1 pm (ET) Learn more
|
| Phased Large Awards for Comparative Effectiveness Research PCORI Funding Announcement | April 28 | April 8, 11:30 am – 12:30 pm (ET) Learn more |
Contact the PCORnet® Front Door to learn how PCORnet can support your patient-centered research.