A collection of articles authored by PCORnet® Network Partners and the Patient-Centered Outcomes Research Institute® (PCORI®) was recently published as a supplement in the February 2026 issue of Medical Care.
Titled, “PCORnet®: Accelerating Patient-Centered Comparative Clinical Effectiveness Research,” the supplement offers an in-depth look at how the PCORnet infrastructure supports patient-centered health research, drives innovation, and enables high-impact research at a national scale.
The supplement features 19 peer-reviewed, open-access articles that highlight the strong scientific value of PCORnet in advancing patient-centered health research. Together, the articles introduce the PCORnet infrastructure, trace the growth of the network over the past decade, showcase inspiring examples of research powered by PCORnet®, explore innovative approaches to engagement and partnership, and share insights from PCORnet® Network Partners on implementing new technologies.
One article in the supplement was collectively written by eight PCORnet® Patient Partners. The article describes a framework for meaningful patient engagement that is “careful, kind, and connected.” This framework builds on lessons learned from patient-partnered research in order to advance, “a collaborative and co-created health research ecosystem that improves outcomes for all.”
“This special issue marks a point of inflection for PCORnet, reflecting substantial progress, shared learning, and future directions for collaboration,” wrote Erin Holve and Kathleen McTigue in their introduction to the supplement. “As the network continues to evolve, the papers are a useful snapshot of the unique features of PCORnet and opportunities for research teams to use PCORnet for national-scale clinical effectiveness research and other health research.”
Articles Featured in the Medical Care Supplement
Overview of PCORnet® and Patient-Centered Clinical Effectiveness Research
- PCORnet®: Accelerating Patient-Centered Comparative Clinical Effectiveness Research
- PCORnet®: A National Resource for Patient-Centered Health Research
Research Papers
- A Roadmap for Accelerating Research in Intellectual and Developmental Disabilities Using PCORnet®
- Characteristics of Pregnancy-related Health Events Across Care Settings Nationwide in PCORnet®
- Development and Value of a Centralized Text Message-based Tracking and Support Program for the PRECIDENTD Study
- Investigating the Use of the Fast Health Care Interoperability Resources (FHIR) Standard to Support Data Activities Across the PCORnet®Infrastructure: Lessons Learned From the FHIR Pilots of the Coordinating Center for PCORnet®
- Lessons Learned from Using PCORnet®to Support the Pathways to Cardiovascular Disease Prevention and Impact of Specialty Referral Among People with HIV from Underrepresented Racial and Ethnic Groups in the Southern United States (PATHWAYS Study)
- PCORnet®: An Infrastructure Supporting Innovation in Clinical Study Design
- PCORnet®: 10 Years of Research Innovation
- Peripartum Telehealth Care Utilization During the COVID-19 Pandemic, by Hypertension Status, PCORnet®, 2018 to 2023
- Preventable Differences in Recommended Outpatient COVID-19 Treatment Among Adults With COVID-19 in the United States
- Racial and Ethnic Differences in COVID-19 Disease Severity Among US Adults in Health Systems Participating in PCORnet®: May 2020 – October 2022
- The ADVANCE Clinical Research Network Past, Present, and Future: Accelerating Partnerships for Patient-Centered Research in Community-Based Primary Care Settings
- The CHI-RON Study: Using PCORnet®and Patient Engagement Strategies to Improve Diversity Among Research Participants in the Congenital Heart Initiative
- Visualizing the Complexity of the PCORnet® Infrastructure and Implications for Designing PCORnet®Studies
Commentaries
- How PCORnet®Could Advance Postmarket Evidence Generation
- Leveraging PCORnet®for Clinical Genetics and the Genomic Learning Health System
- Nothing About Us Without Us: On Publishing the Patient Voice
- Patient Voices Leading Change: A Call to Action for Careful, Kind, and Connected Patient-Partnered Research in PCORnet®
- Partnerships with Health Plans to Link Data from Electronic Health Records to Claims for Research Using PCORnet®
- Research in PCORnet®: One Researcher’s Journey
Contact the PCORnet® Front Door to learn how PCORnet can support your patient-centered research.