Page last updated August 22, 2025
ClinicalTrials.gov#: NCT06964464
Study Design: Intervention Trial
PCORnet Infrastructure: Common Data Model (CDM), Single IRB, Patient partners or engagement
Principal Investigator: Mehmet Aktas
Institution: University of Rochester
PCORnet® Network Partner: External
Funder: Patient-Centered Outcomes Research Institute (PCORI); (Project webpage)
Funding Date: 2024
Study Duration: 2025 – 2031
Participating PCORnet® Clinical Research Networks: GPC, INSIGHT, PaTH, REACHnet
Therapeutic Area: Cardiovascular
Status: Recruiting
Research Question(s):
In this study, we are comparing two commonly used beta-blockers-carvedilol and metoprolol succinate-in people who have heart failure and an implanted defibrillator. We want to find out if carvedilol is more effective than metoprolol succinate at preventing dangerous heart rhythm problems, hospitalizations for heart issues, and deaths caused by heart disease.