PCORnet Reference Materials

PCORnet is a network of networks. A national resource available to everyone.

Thank you for your interest in PCORnet. Below you will find resources about the network that can help you determine if PCORnet is right for your research study.

The PCORnet® Playbook is a great place to start. Its step-by-step guidance is a "how-to" for PCORnet® Studies. Still not sure, or better yet, ready to get started? Contact us at the PCORnet® Front Door.

PCORnet resources are FREE and available to researchers, patient groups, industry, and agencies from all funding sources and affiliations.

Data as of February 2026

PCORnet is well suited to support:

  • Real-world evidence studies
  • Comparative clinical effectiveness research
  • Population health research
  • Pragmatic research
  • Health systems research
  • And more

Learn about these examples in the PCORnet® Playbook (Webpage)

More PCORnet® Playbook Topics of Interest

PCORnet® Studies

Search PCORnet® Studies and filter by Status, Funder or Therapeutic Area (Webpage)

PCORnet® Study Publications

Review primary results from PCORnet® Study publications (Webpage)

Case Studies

Learn how these researchers used the PCORnet infrastructure with case studies (Webpage)

PCORnet® Clinical Research Networks

PCORnet® CRN Site Profiles

Review partner sites profiles for each PCORnet® CRN (Webpage)

PCORnet® is intended to improve the nation’s capacity to efficiently conduct patient-centered health research, particularly comparative clinical effectiveness research (CER), by providing a large, highly representative network of health data, research expertise, and patient insights. PCORnet has been developed with funding from the Patient-Centered Outcomes Research Institute® (PCORI®).